(-)-erythro-1,3-Dihydroxy-2-amino-eicosan | 3530-52-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (-)-erythro-1,3-Dihydroxy-2-amino-eicosan
• 英文别名: 1,3-Eicosanediol,2-amino-,(2R,3S)-rel-；(2R,3S)-2-aminoicosane-1,3-diol
• CAS: 3530-52-7；20180-62-5；24006-62-0；24028-07-7；91685-44-8；98575-69-0；122087-64-3
• 化学式: C₂₀H₄₃NO₂
• 分子量: 329.567
• InChiKey: UFMHYBVQZSPWSS-UXHICEINSA-N

物化性质

• 沸点：
  471.9±25.0 °C(Predicted)
• 密度：
  0.920±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  23
• 可旋转键数：
  18
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  66.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (-)-erythro-1,3-Dihydroxy-2-amino-eicosan 、 邻苯二甲醛 、 2-巯基乙醇 生成 (2R,3S)-2-[1-(2-hydroxyethylsulfanyl)isoindol-2-yl]icosane-1,3-diol
  参考文献：
  名称：

  MERRILL, ALFRED H. , JR.;JR.;WANG, ELAINE;MULLINS, RICHARD E.;CHARLES, W.+, ANAL. BIOCHEM., 171,(1988) N 2, 373-381

  摘要：

  DOI：
• 作为产物：
  描述：

  硬脂烷醛 在 镍 氢气 、 potassium carbonate 作用下， 以 甲醇 、 乙醇 为溶剂， 生成 (-)-erythro-1,3-Dihydroxy-2-amino-eicosan
  参考文献：
  名称：

  鞘脂系列研究（十七）：赤型和苏-C 20-二氢鞘氨醇的合成与拆分

  摘要：

  通过向硝基十八醇中添加硝基乙醇，然后还原赤型和苏型硝基二醇，得到了赤型和苏型-1,3-二羟基-2-氨基二十二烷。用1-谷氨酸拆分得到碱的四种旋光形式。d-构型已分配给+-赤型异构体。

  DOI：

  10.1016/0040-4020(61)80099-9

文献信息

• Mutant endoglycoceramidases with enhanced synthetic activity
  申请人：La Jolla Pharmaceutical Company

  公开号：US10294504B2

  公开（公告）日：2019-05-21

  The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme.

  本发明涉及一种新型内聚甘糖苷酶，其水解活性已大大降低或消除，因此该酶可用于由单糖或寡糖和神经酰胺合成糖脂。更具体地说，内糖化酶是天然存在的内糖化酶的突变体，优选包括酶的活性位点或亲核位点内的突变，更优选包括活性位点或亲核位点内 Glu 残基的取代突变。还公开了一种产生突变型内糖化酶的方法和一种使用这种突变型酶酶解合成糖脂的方法。
• MERRILL, ALFRED H. , JR.;JR.;WANG, ELAINE;MULLINS, RICHARD E.;CHARLES, W.+, ANAL. BIOCHEM., 171,(1988) N 2, 373-381
  作者：MERRILL, ALFRED H. , JR.、JR.、WANG, ELAINE、MULLINS, RICHARD E.、CHARLES, W.+

  DOI：——

  日期：——
• MUTANT ENDOGLYCOCERAMIDASES WITH ENHANCED SYNTHETIC ACTIVITY
  申请人：Seneb Biosciences, Inc.

  公开号：EP1765998B1

  公开（公告）日：2011-09-21
• Mutant Endoglycoceramidases With Enhanced Synthetic Activity
  申请人：Johnson Karl F.

  公开号：US20090170155A1

  公开（公告）日：2009-07-02

  The present invention relates to a novel endoglycoceramidase whose hydrolytic activity has been substantially reduced or eliminated, such that the enzyme is useful for synthesis of glycolipids from a monosaccharide or oligosaccharide and a ceramide. More specifically, the endoglycoceramidase is a mutant version of a naturally occurring endoglycoceramidase, preferably comprising a mutation within the active site or the nucleophilic site of the enzyme and more preferably comprising a substitution mutation of the Glu residue within the active site or the nucleophilic site. Also disclosed are a method for generating the mutant endoglycoceramidase and a method for enzymatically synthesizing glycolipids using this mutant enzyme.
• SOLVENTS FOR MUTANT ENDOGLYCOCERAMIDASES WITH SYNTHETIC ACTIVITY
  申请人：Defrees Shawn

  公开号：US20090176278A1

  公开（公告）日：2009-07-09

  The present invention provides reaction mixtures comprising a solvent having at least one of an alkoxy ether and/or a polyhydric alcohol for use in reactions with a mutant endoglycoceramidase having enhanced synthetic activity.