5-isopropyl-[1,2,4]triazolo[1,5-a]pyrimidine | 5782-72-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 三唑并嘧啶类
• 英文名称: 5-isopropyl-[1,2,4]triazolo[1,5-a]pyrimidine
• 英文别名: 5-Propan-2-yl-[1,2,4]triazolo[1,5-a]pyrimidine
• CAS: 5782-72-9
• 化学式: C₈H₁₀N₄
• 分子量: 162.194
• InChiKey: ABHIPOGIICRWSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  43.1
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• TISSUE-NONSPECIFIC ALKALINE PHOSPHATASE (TNAP) ACTIVATORS AND USES THEREOF
  申请人：Millan Jose Luis

  公开号：US20090053192A1

  公开（公告）日：2009-02-26

  Disclosed herein are tissue-nonspecific alkaline phosphatase (TNAP) activators and uses thereof for promoting bone mineral deposition.

  本文披露了组织非特异性碱性磷酸酶(TNAP)的激活剂及其用途，用于促进骨矿物质沉积。
• INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1
  申请人：CELGENE QUANTICEL RESEARCH, INC.

  公开号：US20160304516A1

  公开（公告）日：2016-10-20

  The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of lysine specific demethylase-1. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
• 1,2,4-OXADIAZOLE DERIVATIVES AS HISTONE DEACETYLASE 6 INHIBITORS
  申请人：Oryzon Genomics, S.A.

  公开号：US20200339569A1

  公开（公告）日：2020-10-29

  The invention relates to compounds of Formula (I) as described herein, useful as histone deacetylase 6 (HDAC6) inhibitors. The invention also relates to pharmaceutical compositions comprising these compounds and to their use in therapy.
• US9944636B2
  申请人：——

  公开号：US9944636B2

  公开（公告）日：2018-04-17