1-{4'-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-3-oxopropyl]biphenyl-3-yl}-1-methyl-3-pentyl urea | 869090-05-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{4'-[3-(4(S)-benzyl-2-oxooxazolidin-3-yl)-2(S)-ethoxy-3-oxopropyl]biphenyl-3-yl}-1-methyl-3-pentyl urea
• 英文别名: 1-[3-[4-[(2S)-3-[(4S)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-2-ethoxy-3-oxopropyl]phenyl]phenyl]-1-methyl-3-pentylurea
• CAS: 869090-05-1
• 化学式: C₃₄H₄₁N₃O₅
• 分子量: 571.717
• InChiKey: WDUCVVWPLIHUEN-CONSDPRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  42
• 可旋转键数：
  13
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  88.2
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE PPARgamma-TYPE RECEPTORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS<br/>[FR] NOUVEAUX COMPOSES BIAROMATIQUES ACTIVANT DES RECEPTEURS DE TYPE PPAR DOLLAR G(G), LEUR PROCESSUS DE PREPARATION ET LEUR UTILISATION DANS DES COMPOSITIONS COSMETIQUES OU PHARMACEUTIQUES
  申请人：GALDERMA RES & DEV

  公开号：WO2005108352A1

  公开（公告）日：2005-11-17

  The invention relates to novel biaromatic compounds which correspond to the following general formula (I) and to their method of preparation and to their use in pharmaceutical compositions intended for use in human or veterinary medicine, in particular in dermatology as well as in the field of cardiovascular diseases, immune diseases and/or diseases related to the metabolism of lipids, or alternatively in cosmetic compositions.

  该发明涉及与以下一般式（I）相对应的新型双芳香化合物，以及它们的制备方法和它们在人类或兽医医学中的药物组合物中的使用，特别是在皮肤病学领域以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域，或者在化妆品组合物中的使用。
• Novel biaromatic compounds which activate PPARy-type receptors and cosmetic/pharmaceutical compositions comprised thereof
  申请人：Aubert Jerome

  公开号：US20070112070A1

  公开（公告）日：2007-05-17

  Novel biaromatic compounds having the following structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, in particular in dermatology as well as in the fields of cardiovascular diseases, immune diseases and/or diseases related to the metabolism of lipids, or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香化合物被配制成适用于人类或兽医药物治疗的制剂，特别是在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域，或者制成化妆品制剂。
• Methods for activating PPAR gamma-type receptors
  申请人：Aubert Jerome

  公开号：US20100035988A1

  公开（公告）日：2010-02-11

  Novel biaromatic compounds having the following structural formula (I): are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine, in particular in dermatology as well as in the fields of cardiovascular diseases, immune diseases and/or diseases related to the metabolism of lipids, or, alternatively, into cosmetic compositions.

  具有以下结构式（I）的新型双芳香化合物被配制成适用于人类或兽医药物的制剂，特别是在皮肤科以及心血管疾病、免疫疾病和/或与脂质代谢相关的疾病领域中，或者配制成化妆品制剂。
• NOVEL BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR&gammad;-TYPE RECEPTORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：Galderma Research & Development, S.N.C.

  公开号：EP1742608A1

  公开（公告）日：2007-01-17
• BIAROMATIC COMPOUNDS WHICH ACTIVATE PPAR(GAMMA) TYPE RECEPTORS, THEIR PROCESS OF PREPARATION AND THEIR USE IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
  申请人：Galderma Research & Development

  公开号：EP1742608B1

  公开（公告）日：2010-02-24