5-[(4,6-dimethyl-pyridin-2-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione | 25165-71-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-[(4,6-dimethyl-pyridin-2-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione
• 英文别名: 5-[[(4,6-Dimethylpyridin-2-yl)amino]methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione
• CAS: 25165-71-3
• 化学式: C₁₄H₁₆N₂O₄
• 分子量: 276.292
• InChiKey: GACOHKZFUCXMSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  77.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  5-[(4,6-dimethyl-pyridin-2-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione 以 二苯醚 为溶剂， 反应 0.08h， 以80%的产率得到5,7-dimethyl-1H-[1,8]naphthyridin-4-one
  参考文献：
  名称：

  Synthesis of 1,8‐Naphthyridine‐4(1H)‐one Sulfonamides by Thermolysis of 2‐Aminopyridinemethylene (Meldrum's Acid) Derivative

  摘要：

  An efficient synthesis of 1,8-naphthyridine-4(1H)-one sulfonamide derivatives by thermolysis of 2-pyridylaminomethylene (Meldrum's acid derivative) starting from 4,6-dimethyl-2-aminopyridine (1) is described.

  DOI：

  10.1080/00397910701648744
• 作为产物：
  描述：

  丙二酸环(亚)异丙酯 、 2-氨基-4,6-二甲基吡啶 、 原甲酸三甲酯 反应 3.0h， 以70%的产率得到5-[(4,6-dimethyl-pyridin-2-ylamino)-methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione
  参考文献：
  名称：

  Synthesis of 1,8‐Naphthyridine‐4(1H)‐one Sulfonamides by Thermolysis of 2‐Aminopyridinemethylene (Meldrum's Acid) Derivative

  摘要：

  An efficient synthesis of 1,8-naphthyridine-4(1H)-one sulfonamide derivatives by thermolysis of 2-pyridylaminomethylene (Meldrum's acid derivative) starting from 4,6-dimethyl-2-aminopyridine (1) is described.

  DOI：

  10.1080/00397910701648744

文献信息

• Synthesis of 1,8‐Naphthyridine‐4(1<i>H</i>)‐one Sulfonamides by Thermolysis of 2‐Aminopyridinemethylene (Meldrum's Acid) Derivative
  作者：Luiz Everson da Silva、Antonio Carlos Joussef、Ricardo José Nunes、Kely Navakoski de Oliveira

  DOI：10.1080/00397910701648744

  日期：2007.12.1

  An efficient synthesis of 1,8-naphthyridine-4(1H)-one sulfonamide derivatives by thermolysis of 2-pyridylaminomethylene (Meldrum's acid derivative) starting from 4,6-dimethyl-2-aminopyridine (1) is described.