1-Phenyl-2-piperidinohexan | 10351-03-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Phenyl-2-piperidinohexan
• 英文别名: 1-(1-benzyl-pentyl)-piperidine；1-(1-Phenylhexan-2-yl)piperidine
• CAS: 10351-03-8
• 化学式: C₁₇H₂₇N
• 分子量: 245.408
• InChiKey: BMPDBJSIWOKYAN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  18
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• Novel indole derivatives
  申请人：H. Lundbeck A/S

  公开号：US20030050307A1

  公开（公告）日：2003-03-13

  The invention provide compounds of the formula 1 wherein X represents O or S; n is 2, 3, 4, 5, 6, 7, 8, 9 or 10; m is 2 or 3; Y represents N, C or CH; and the dotted line represents an optional bond; R 1 , R 1′ , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 and R 12 are as defined in the description. The compounds are ligands of the 5-HT 1a -receptor.

  该发明提供了化合物的公式1，其中X代表O或S；n为2、3、4、5、6、7、8、9或10；m为2或3；Y代表N、C或CH；虚线代表可选键；R1、R1'、R2、R3、R4、R5、R6、R7、R8、R9、R10、R11和R12如描述中所定义。这些化合物是5-HT1a受体的配体。
• Novel heteroaryl derivatives, their preparation and use
  申请人：H. Lundbeck A/S

  公开号：US20030050306A1

  公开（公告）日：2003-03-13

  A heteroaryl derivative having the formula (I) 1 any of its enantiomers or any mixture thereof, wherein X is —O—, —S—, or CR 4 R 5 —; and Y is —CR 6 R 7 ; —CR 6 R 7 —CR 8 R 9 —, or —CR 6 —CR 7 ; or X and Y together form a group —CR 4 ═R 5 —, or —CR 4 ═CR 5 —CR 6 R 7 —; Z is —O—, or —S—; W is N, C, or CH; n is 2, 3, 4, 5, 6, 7, 8, 9 or 10; m is 2 or 3; A is O or S wherein the doted lines mean an optional bond. The compounds of the invention are considered useful for the treatment of affective disorders such as general anxiety disorder, panic disorder, obsessive compulsive disorder, depression, social phobia and eating disorders, and neurological disorders such as psychosis.

  具有以下结构式(I)的杂环芳基衍生物，其中X为—O—、—S—或CR4R5—；Y为—CR6R7、—CR6R7—CR8R9—或—CR6—CR7；或者X和Y一起形成一个基团—CR4═R5—或—CR4═CR5—CR6R7—；Z为—O—或—S—；W为N、C或CH；n为2、3、4、5、6、7、8、9或10；m为2或3；A为O或S，其中点线表示可选键。该发明的化合物被认为对治疗情感障碍，如广泛性焦虑障碍、恐慌障碍、强迫症、抑郁症、社交恐惧症和进食障碍，以及神经症如精神病等是有用的。
• Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use
  申请人：H. Lundbeck A/S

  公开号：US20020035113A1

  公开（公告）日：2002-03-21

  A piperidine, tetrahydropyridine or piperazine derivative having formula (I), 1 any of its enantiomers or any mixture thereof, or an acid addition salt thereof, wherein B is C 1-10 -alkylene, C 1-10 -alkenylene or C 1-10 -alkynylene; X is —O—, —S—, or CR 4 R 5 —; and Y is —CR 6 R 7 , —CR 6 R 7 —CR 8 R 9 , or CR 6 ═CR 7 —; or X and Y together form a group —CR 4 ═CR 5 , or —CR 4 —CR 5 —CR 6 R 7 —; Z is —O—, or —S—; W is N, C, or CH, and the dotted line is an optional bond; A is a bicyclic ring selected from (Ia) or (Ib) wherein E 1 , E 2 and E 3 are selected from O, S, N, NR 11 , C, CR 12 and CHR 13 , and the dotted line indicates an optional bond, provided that E 2 and E 1 and/or E 3 may not simultaneously be O, or S. The compounds of the invention are considered useful for the treatment of affective disorders, such as depression, psychosis, anxiety disorders including general anxiety disorder, panic disorder, obsessive compulsive disorder, and eating disorders.

  一种具有公式（I）的哌啶，四氢吡啶或哌嗪衍生物，其中B为C1-10-烷基，C1-10-烯基或C1-10-炔基; X为—O—，—S—或CR4R5—; Y为—CR6R7，—CR6R7—CR8R9或CR6═CR7—; 或X和Y一起形成一个群组—CR4═CR5，或—CR4—CR5—CR6R7—; Z为—O—或—S—; W为N，C或CH，虚线为可选键; A为从（Ia）或（Ib）中选择的双环环，其中E1，E2和E3选择自O，S，N，NR11，C，CR12和CHR13，并且虚线表示可选键，前提是E2和E1和/或E3不能同时为O或S。本发明的化合物被认为对治疗情感障碍有用，例如抑郁症，精神病，焦虑症，包括普通焦虑症，恐慌症，强迫症和进食障碍。
• Indole and 2,3-dihydroindole derivatives, their preparation and use
  申请人：H. Lundbeck A/S

  公开号：US20030018050A1

  公开（公告）日：2003-01-23

  The present invention relates to indole and 2,3-dihydroindole derivatives having formula (I) 1 or any of its any of its enantiometers or any mixture thereof, or an acid addition salt thereof, wherein A, R 1 , R 2 , R 3 , W, X, Y and Z are as described in the description. The compounds are potent serotonin reuptake inhibitors and have 5-HT 1A receptor antagonistic activity.

  本发明涉及具有式(I)1或其任何对映体或其任何混合物或其酸加成盐的吲哚和2,3-二氢吲哚衍生物，其中A、R1、R2、R3、W、X、Y和Z如描述中所述。这些化合物是有效的5-羟色胺再摄取抑制剂，并具有5-HT1A受体拮抗活性。
• INDOLE AND 2,3-DIHYDROINDOLE DERIVATIVES, THEIR PREPARATION AND USE
  申请人：Roche Diagnostics GmbH

  公开号：EP1007523A1

  公开（公告）日：2000-06-14