N1-(pyrrolidine)cyanoguanidine | 1351353-96-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: N1-(pyrrolidine)cyanoguanidine
• 英文别名: N'-cyanopyrrolidine-1-carboximidamide
• CAS: 1351353-96-2
• 化学式: C₆H₁₀N₄
• 分子量: 138.172
• InChiKey: UVTRPISMDGQJKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  65.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N1-(pyrrolidine)cyanoguanidine 在 盐酸 作用下， 以 水 为溶剂， 反应 12.0h， 以55%的产率得到N-carbamoylpyrolidine-1-carboxyimidamide hydrochloride
  参考文献：
  名称：

  구아니딘 화합물 및 이의 용도

  摘要：

  This is the translation of the text into Chinese: 本发明涉及瓜尼啶化合物及其用途，更详细地涉及表现出优越的抑制癌细胞增殖、抑制癌转移和癌复发的瓜尼啶衍生物，其制备方法以及含有其作为有效成分的药学组合物。

  公开号：

  KR20150051016A
• 作为产物：
  描述：

  sodium dicyanamide 生成 N1-(pyrrolidine)cyanoguanidine
  参考文献：
  名称：

  N1-Cyclic Amine-N5-Substituted Phenyl Biguanide Derivatives, Methods of Preparing the Same and Pharmaceutical Composition Comprising the Same

  摘要：

  提供了一种公式1的N1-环状胺-N5-取代苯基双胍衍生物或其药学上可接受的盐，以及制造该衍生物的方法和包括该双胍衍生物或其药学上可接受的盐作为活性成分的药物组合物。这些双胍衍生物具有抑制癌细胞增殖的效果，并且还表现出抗癌活性，包括抑制癌症转移和癌症复发，因为它们能够有效激活与能量代谢控制相关的AMPK，即使与传统药物相比，以小剂量给药也很有效。此外，这些双胍衍生物通过AMPK激活具有降低血糖和血脂浓度的高度效果，因此它们可有效用于治疗糖尿病、肥胖症、高脂血症、高胆固醇血症、脂肪肝、冠状动脉疾病、骨质疏松症、多囊卵巢综合症和代谢综合症。

  公开号：

  US20140179660A1

文献信息

• [EN] GUANIDINE COMPOUNDS AND USE THEREOF<br/>[FR] COMPOSÉS DE GUANIDINE ET LEUR UTILISATION
  申请人：HANALL BIOPHARMA CO LTD

  公开号：WO2015160220A1

  公开（公告）日：2015-10-22

  The present invention relates to guanidine compounds for inhibiting mitochondrial oxidative phosphorylation (OXPHOS) and use thereof. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating a OXPHOS-related disease, particularly cancer by inhibiting mitochondrial oxidative phosphorylation and reprogramming cellular metabolism.

  本发明涉及用于抑制线粒体氧化磷酸化（OXPHOS）的胍啉化合物及其使用。更具体地，本发明涉及一种用于预防或治疗与OXPHOS相关的疾病，特别是通过抑制线粒体氧化磷酸化和重编程细胞代谢的药物组合物。
• BIGUANIDE COMPOUNDS AND USE THEREOF
  申请人：HANALL BIOPHARMA CO., LTD.

  公开号：US20150126518A1

  公开（公告）日：2015-05-07

  The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof.

  本发明涉及双胍类化合物及其使用，更具体地涉及表现出对抑制癌细胞增殖、抑制癌转移和复发具有优异效果的双胍衍生物，以及制备该化合物的方法、含有该化合物作为活性成分的药物组合物，以及包括向需要的受试者施用所述组合物的有效量的步骤的癌症预防或治疗方法。
• 바이구아나이드 화합물 및 이의 용도
  申请人：IMMUNOMET THERAPEUTICS INC. 이뮤노메트테라퓨틱스 인코포레이티드(520150627264)

  公开号：KR20210014090A

  公开（公告）日：2021-02-08

  본 발명은 바이구아나이드 화합물 및 이의 용도에 관한 것으로서, 더욱 자세하게는 암세포 증식 억제, 암 전이와 암 재발을 억제에 우수한 효과를 나타내는 바이구아나이드 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 약학 조성물에 관한 것이다.

  This is the translation of the text you provided: This invention relates to biguanide compounds and their uses, more specifically to biguanide derivatives that exhibit excellent effects in inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence, as well as to a method for producing them and pharmaceutical compositions containing them as active ingredients.
• [EN] COMPOUNDS AND METHODS OF TREATING CANCER<br/>[FR] COMPOSÉS ET PROCÉDÉS DE TRAITEMENT DU CANCER
  申请人：UNIV CALIFORNIA

  公开号：WO2013188452A1

  公开（公告）日：2013-12-19

  Presented herein inter alia are novel compounds and methods of using the same for the treatment of cancers.

  本文介绍了新颖的化合物以及利用这些化合物治疗癌症的方法。
• N1-Cyclic Amine-N5-Substituted Biguanide Derivatives, Methods of Preparing the Same and Pharmaceutical Composition Comprising the Same
  申请人：Kim Sung Wuk

  公开号：US20140179661A1

  公开（公告）日：2014-06-26

  A N1-cyclic amine-N5-substituted biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs. Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.

  提供了一种公式1的N1-环氨基-N5-取代双胍衍生物或其药用盐，以及制造该衍生物的方法，以及包含双胍衍生物或其药用盐作为活性成分的药物组合物。这些双胍衍生物具有抑制癌细胞增殖的效果，并且还表现出抗癌活性，包括抑制癌症转移和癌症复发，因为它们在与传统药物相比仅需小剂量时，能有效激活与能量代谢控制相关的AMPK。此外，双胍衍生物通过激活AMPK在降低血糖和血脂浓度方面具有很高的效果，因此它们可能有效用于治疗糖尿病、肥胖症、高脂血症、高胆固醇血症、脂肪肝、冠状动脉疾病、骨质疏松症、多囊卵巢综合征和代谢综合征。