3,4-Dimethyl-5-hydroxy-benzoesaeure-methylester | 91061-37-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,4-Dimethyl-5-hydroxy-benzoesaeure-methylester
• 英文别名: 3-hydroxy-4,5-dimethyl-benzoic acid methyl ester；3-Hydroxy-4,5-dimethyl-benzoesaeure-methylester；Methyl 3-hydroxy-4,5-dimethylbenzoate
• CAS: 91061-37-9
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: WRXQUHHOMXXQCK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,4-Dimethyl-5-hydroxy-benzoesaeure-methylester 在 氢氧化钾 作用下， 生成 3,4-Dimethyl-5-hydroxy-benzoesaeure
  参考文献：
  名称：

  REACTION OF ANHYDROSEPEDONIN WITH ALKALI SYNTHESIS OF A DEGRADATION PRODUCT AND SOME RELATED DIMETHYLHYDROXYBENZOIC ACIDS

  摘要：

  从无水石蕈酮与碱反应中分离出两种产物，并鉴定为3-羟基-5-甲基苯甲酸和3,4-二甲基-5-羟基苯甲酸。后一化合物的结构通过明确的合成得到确认。在这项工作中，还制备了从o-二甲苯衍生的其余o-和m-羟基苯甲酸。

  DOI：

  10.1139/v64-010
• 作为产物：
  描述：

  5-Amino-3,4-dimethyl-benzoesaeure-methylester 生成 3,4-Dimethyl-5-hydroxy-benzoesaeure-methylester
  参考文献：
  名称：

  REACTION OF ANHYDROSEPEDONIN WITH ALKALI SYNTHESIS OF A DEGRADATION PRODUCT AND SOME RELATED DIMETHYLHYDROXYBENZOIC ACIDS

  摘要：

  从无水石蕈酮与碱反应中分离出两种产物，并鉴定为3-羟基-5-甲基苯甲酸和3,4-二甲基-5-羟基苯甲酸。后一化合物的结构通过明确的合成得到确认。在这项工作中，还制备了从o-二甲苯衍生的其余o-和m-羟基苯甲酸。

  DOI：

  10.1139/v64-010

文献信息

• Comparison of 0.1% dexamethasone phosphate eye gel (Dexagel) and 1% prednisolone acetate eye suspension in the treatment of post-operative inflammation after cataract surgery
  作者：Hans Struck、Annett Bariszlovich

  DOI：10.1007/s004170100346

  日期：2001.10

  A prospective, multi-centre, clinical parallel group study was conducted to assess the efficacy and safety of a new 0.1% dexamethasone phosphate eye gel (Group 1, n = 117) compared to 1% prednisolone acetate eye suspension (Group 21, n = 119) in a total of 236 patients (safety population), aged 39-92 years, following cataract surgery. Both drugs were given four times a day for 14 days starting 24 +/- 4 h after surgery. Criteria for evaluation were the reduction in anterior chamber flare and inflammation severity score (primary efficacy criteria) as well as different secondary efficacy and safety evaluation criteria. Laser photometry (LFM-500, Kowa), slit lamp assessment and the examination of other objective and subjective symptoms of ocular discomfort were performed between the last preoperative and 14th post-operative day. There were no statistically significant differences between the treatment groups concerning primary and secondary efficacy criteria. The mean reduction in anterior chamber flare from day I to day 14 post-operatively was 8.34 +/- 20.80 photons/ms with 0.1% dexamethasone eye gel and 5.72 +/- 16.70 photons/ms with 1% prednisolone eye suspension. The mean reduction of inflammation severity score was 1.8 +/- 1.3 points in Group 1 and 2.0 +/- 1.1 points in Group 2. Intra-ocular pressure did not increase after treatment with 0.1% dexamethasone phosphate eye gel. Conclusion: the results of the study underline the protective effect of topically applied 0.1% dexamethasone phosphate eye gel on the blood-aqueous barrier. This drug is an effective and safe steroidal antiinflammatory agent for topical use following cataract surgery and intraocular lens implantation.
• US7244730B2
  申请人：——

  公开号：US7244730B2

  公开（公告）日：2007-07-17
• [EN] MULTIMERIC PROTECTED FLUORESCENT REAGENTS<br/>[FR] RÉACTIFS FLUORESCENTS PROTÉGÉS MULTIMÈRES
  申请人：PACIFIC BIOSCIENCES CALIFORNIA

  公开号：WO2016126941A1

  公开（公告）日：2016-08-11

  Multimeric protected fluorescent reagents and their methods of synthesis are provided. The reagents are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The reagents contain fluorescent dye elements, that allow the compounds to be detected with high sensitivity at desirable wavelengths, binding elements, that allow the compounds to be recognized specifically by target biomolecules, and protective shield elements, that decrease undesirable contacts between the fluorescent dye elements and the bound target biomolecules and that therefore decrease photodamage of the bound target biomolecules by the fluorescent dye elements. The reagents also contain coupling elements connect monomeric compounds into multimeric forms, thereby increasing brightness.
• REACTION OF ANHYDROSEPEDONIN WITH ALKALI SYNTHESIS OF A DEGRADATION PRODUCT AND SOME RELATED DIMETHYLHYDROXYBENZOIC ACIDS
  作者：P. V. Divekar、L. C. Vining

  DOI：10.1139/v64-010

  日期：1964.1.1

  Two products have been isolated from the reaction of anhydrosepedonin with alkali and identified as 3-hydroxy-5-methyl benzoic acid and 3,4-dimethyl-5-hydroxybenzoic acid. The structure of the latter compound was established by unambiguous synthesis. In the course of this work the remaining o- and m-hydroxybenzoic acids derived from o-xylene were also prepared.

  从无水石蕈酮与碱反应中分离出两种产物，并鉴定为3-羟基-5-甲基苯甲酸和3,4-二甲基-5-羟基苯甲酸。后一化合物的结构通过明确的合成得到确认。在这项工作中，还制备了从o-二甲苯衍生的其余o-和m-羟基苯甲酸。