ethyl 4-(3-benzoylphenyl)-3-oxopentanoate | 145927-45-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl 4-(3-benzoylphenyl)-3-oxopentanoate
• CAS: 145927-45-3
• 化学式: C₂₀H₂₀O₄
• 分子量: 324.376
• InChiKey: DDFQJXGXFPCKDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  ethyl 4-(3-benzoylphenyl)-3-oxopentanoate 生成 ethyl 4-(1-(3-benzoylphenyl)ethyl)-2-methylamino-5-thiazolecarboxylate
  参考文献：
  名称：

  Thiazole derivatives

  摘要：

  一种新的噻唑衍生物，其通式如下[1]，以及其药用盐：##STR1## 其中A是一个单键，一条直链或支链的低碳烷基基团或一条直链或支链的低碳烯基基团；B是一个单键或--CO--; R.sup.1是一个羧基或--CON(R.sup.7)OR.sup.8（R.sup.7和R.sup.8分别独立地是氢原子或低烷基基团）；R.sup.2是一个低烷基基团；R.sup.3和R.sup.4分别独立地是氢原子、低烷基基团或低烷氧羰基基团；R.sup.5是一个氢原子或卤原子；R.sup.6是一个氢原子、卤原子、低烷基基团、羟基、低烷氧基团、硫醇基团、低烷硫基团、低烷基亚硫基团、低烷基砜基团、低烷基砜基团、硝基基团、氨基团、取代氨基团、氰基团、羧基或酰基。本发明的化合物可用作自身免疫性疾病和炎症性疾病的治疗或预防药物。

  公开号：

  US05258396A1

文献信息

• [EN] CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES<br/>[FR] ARYLCETONES CHIRALES UTILISEES POUR TRAITER DES MALADIES INFLAMMATOIRES DEPENDANT DES NEUTROPHILES
  申请人：DOMPE SPA

  公开号：WO2004052830A1

  公开（公告）日：2004-06-24

  ABSTRACT The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

  摘要 公式(I)的化合物：其中Ar是芳香环，Ra，Rb如描述中所定义，可用作治疗药物，用于治疗由IL-8诱导的中性粒细胞浸润介导的疾病，如牛皮癣、类风湿关节炎、溃疡性结肠炎以及用于治疗缺血再灌注引起的损伤。
• Chiral arylketones in the treatment of neutrophil-dependent inflammatory diseases
  申请人：Allegretti Marcello

  公开号：US20060247297A1

  公开（公告）日：2006-11-02

  The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

  化合物的公式（I）：其中Ar是芳香环，Ra，Rb如描述中定义的那样，可用作治疗剂，用于治疗由IL-8诱导的中性粒细胞浸润介导的疾病，如牛皮癣，类风湿性关节炎，溃疡性结肠炎，并用于治疗缺血再灌注所致的损伤。
• CHIRAL ARYLKETONES IN THE TREATMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DISEASES
  申请人：ALLEGRETTI Marcello

  公开号：US20090203652A1

  公开（公告）日：2009-08-13

  The compounds of formula (I): where Ar is an aromatic ring and Ra, Rb, are as defined in the description, are useful in therapy as drugs for the treatment of diseases mediated by infiltrations of neutrophils induced by IL-8, such as psoriasis, rheumatoid arthritis, ulcerative cholitis and for the treatment of damages caused by ischemia and reperfusion.

  公式（I）的化合物：其中Ar是芳香环，Ra，Rb如描述中所定义，可用于治疗由IL-8介导的中性粒子浸润引起的疾病，如牛皮癣，类风湿性关节炎，溃疡性结肠炎以及治疗缺血再灌注所致的损伤，作为药物在疗法上是有用的。
• Novel thiazole derivatives
  申请人：SUMITOMO PHARMACEUTICALS COMPANY, LIMITED

  公开号：EP0511021A1

  公开（公告）日：1992-10-28

  A novel thiazole derivative of formula [1] or a pharmaceutically acceptable salt thereof: wherein A is a singe bond, straight-chained or branched-chained lower alkylene or straight-chained or branched lower alkenylene, B is a single bond or -CO-; R¹ is carboxy or -CON(R⁷)OR⁸ (R⁷ and R⁸ are the same or different and each is hydrogen or lower alkyl); R² is lower alkyl; R³ and R⁴ are the same or different and each is hydrogen, lower alkyl or lower alkoxycarbonyl; R⁵ is hydrogen or halogen; and R⁶ is hydrogen, halogen, lower alkyl, hydroxy, lower alkoxy, thiol, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, substituted amino, cyano, carboxy or acyl. The compounds of the present invention are useful as therapeutic or preventive drugs for autoimmune diseases and inflammatory diseases.

  式[1]的新型噻唑衍生物或其药学上可接受的盐： 其中 A 为单键、直链或支链低级亚烷基或直链或支链低级烯基，B 为单键或-CO-；R¹ 为羧基或-CON(R⁷)OR⁸ (R⁷ 和 R⁸ 相同或不同，且各自为氢或低级烷基)；R² 为低级烷基；R³和R⁴相同或不同，且各自为氢、低级烷基或低级烷氧基羰基；R⁵为氢或卤素；以及R⁶为氢、卤素、低级烷基、羟基、低级烷氧基、硫醇、低级烷硫基、低级烷基亚磺酰基、低级烷基磺酰基、硝基、氨基、取代氨基、氰基、羧基或酰基。 本发明的化合物可作为治疗或预防自身免疫性疾病和炎症性疾病的药物。
• CHIRAL ARYLKETONES IN THE TREATEMENT OF NEUTROPHIL-DEPENDENT INFLAMMATORY DESEASES
  申请人：Dompé S.P.A.

  公开号：EP1581474A1

  公开（公告）日：2005-10-05