N-(3,4-dimethyl-phenyl)-2-(2-methyl-benzoimidazol-1-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide | 1111733-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3,4-dimethyl-phenyl)-2-(2-methyl-benzoimidazol-1-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide
• 英文别名: N-(3,4-dimethylphenyl)-2-(2-methylbenzimidazol-1-yl)-N-[2-[4-(trifluoromethyl)phenyl]ethyl]acetamide
• CAS: 1111733-87-9
• 化学式: C₂₇H₂₆F₃N₃O
• 分子量: 465.518
• InChiKey: YZARMSHDTYKMDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  38.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-bromo-N-(3,4-dimethyl-phenyl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide 、 2-甲基苯并咪唑 生成 N-(3,4-dimethyl-phenyl)-2-(2-methyl-benzoimidazol-1-yl)-N-[2-(4-trifluoromethyl-phenyl)-ethyl]-acetamide
  参考文献：
  名称：

  MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS

  摘要：

  本发明涉及式I的化合物，其中Ar，R1，R2，R3，R4，R5，n，o和p如本文所定义，或其药学适用的酸盐加合物，光学纯对映体，外消旋体或其二对映异构体混合物。式I的化合物可用于治疗睡眠障碍，如睡眠呼吸暂停，嗜睡症，失眠，睡眠障碍，时差综合症，昼夜节律紊乱或与神经系统疾病相关的睡眠障碍。

  公开号：

  US20090036422A1

文献信息

• METHOD AND APPARATUS FOR ENHANCED MINIMAL SHEAR MOLDING UTILIZING EXTRUSIONAL, PELLETIZATION, AND MELT RHEOLOGICAL CONTROL OF PELLETS AND MICROPELLETS AND MOLDED OBJECTS MADE THEREFROM
  申请人：Tornow Matthew

  公开号：US20090062427A1

  公开（公告）日：2009-03-05

  The present invention relates to a method for enhancement of the minimal shear molding process utilizing pellets and/or micropellets produced through controlled extrusional and pelletization processes in combination with nonpowder melt flow rheology that incorporates reduced molding temperature and/or reduced cure time, reduced rotation axis ratios and/or reduced rotation rates. Molding can be uniaxial, biaxial, or multiaxial rotational or oscillatory or both. The molded items produced can be single or multiple layers and can be produced in one or more molding sequences using similar or different chemical compositions.