5-chloro-N-(5-chloropyridin-2-yl)-3-hydroxy-2-{[4-(1-{2-[(1-methylpiperidin-4-yl)oxy]ethyl}-2-oxo-1,2-dihydropyridine-3-yl)benzenoyl]amino}benzamide | 936692-43-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-chloro-N-(5-chloropyridin-2-yl)-3-hydroxy-2-{[4-(1-{2-[(1-methylpiperidin-4-yl)oxy]ethyl}-2-oxo-1,2-dihydropyridine-3-yl)benzenoyl]amino}benzamide
• 英文别名: 5-chloro-N-(5-chloropyridin-2-yl)-3-hydroxy-2-{[4-(1-{2-[(1-methylpiperidin-4-yl)oxy]ethyl}-2-oxo-1,2-dihydropyridin-3-yl)benzoyl]amino}benzamide；5-chloro-N-(5-chloropyridin-2-yl)-3-hydroxy-2-[[4-[1-[2-(1-methylpiperidin-4-yl)oxyethyl]-2-oxopyridin-3-yl]benzoyl]amino]benzamide
• CAS: 936692-43-2
• 化学式: C₃₂H₃₁Cl₂N₅O₅
• 分子量: 636.535
• InChiKey: SXEACHKJPXFERA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• BENZENE DERIVATIVE OR SALT THEREOF
  申请人：Hirayama Fukushi

  公开号：US20090054352A1

  公开（公告）日：2009-02-26

  Problem: To provide compounds which have an anticoagulation effect based on their ability to inhibit the activated blood coagulation factor X and are useful as coagulation inhibitors or agents for prevention or treatment for diseases caused by thrombi or emboli. Means for Solution: Benzene derivatives or their salts having a characteristic chemical structure with a phenol ring and a benzene ring bonding to each other via an amide bond, in which the phenol ring further bonds to a benzene ring or a heteroaryl ring via an amide bond. They have an excellent effect of inhibiting the activated blood coagulation factor X, and especially have an excellent oral activity.

  问题：提供具有抗凝作用的化合物，其基于其抑制活化的血液凝血因子X的能力，并且可用作凝血抑制剂或用于预防或治疗由血栓或栓子引起的疾病的药物。 解决方法：苯衍生物或其盐具有特征化学结构，其中苯酚环和苯环通过酰胺键相互结合，其中苯酚环通过酰胺键进一步结合到苯环或杂环环上。它们具有出色的抑制活化的血液凝血因子X的效果，尤其是具有出色的口服活性。
• US8022208B2
  申请人：——

  公开号：US8022208B2

  公开（公告）日：2011-09-20