Methyl 3-(1-amino-2-hydroxyethyl)benzoate hcl | 373648-81-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 3-(1-amino-2-hydroxyethyl)benzoate hcl
• 英文别名: methyl 3-(1-amino-2-hydroxyethyl)benzoate;hydrochloride
• CAS: 373648-81-8
• 化学式: C10H14ClNO3
• 分子量: 231.67
• InChiKey: SWIJKZSHJUALNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.89
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  72.6
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Amide compounds as kinase inhibitors, compositions and methods of treatment
  申请人：TRANSLATIONAL DRUG DEVELOPMENT, LLC

  公开号：US10738007B2

  公开（公告）日：2020-08-11

  The present disclosure relates to certain amides and heterocyclic compounds. The present disclosure also relates to uses of these compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graft versus host disease (GVHD), inflammation, cardiovascular disorders, central nervous system disorders, and neoplastic disorders.

  本公开涉及某些酰胺和杂环化合物。本公开还涉及这些化合物在抑制 Rho- 相关蛋白激酶和治疗疾病方面的用途，这些疾病包括自身免疫性疾病、移植物抗宿主疾病（GVHD）、炎症、心血管疾病、中枢神经系统疾病和肿瘤性疾病。
• AMIDE COMPOUNDS AS KINASE INHIBITORS, COMPOSITIONS AND METHODS OF TREATMENT
  申请人：TRANSLATIONAL DRUG DEVELOPMENT, LLC

  公开号：US20190248744A1

  公开（公告）日：2019-08-15

  The present disclosure relates to certain amides and heterocyclic compounds. The present disclosure also relates to uses of these compounds to inhibit Rho-associated protein kinases and treat diseases including autoimmune disorders, graft versus host disease (GVHD), inflammation, cardiovascular disorders, central nervous system disorders, and neoplastic disorders.