N-Benzyl-N-hydroxymethyl-acetamid | 99075-22-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyl-N-hydroxymethyl-acetamid
• 英文别名: N-benzyl-N-(hydroxymethyl)acetamide
• CAS: 99075-22-6
• 化学式: C₁₀H₁₃NO₂
• 分子量: 179.219
• InChiKey: QOZUSNFVPYTPDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT<br/>[FR] LIEUR PIPÉCOLIQUE ET SON UTILISATION POUR UNE CHIMIE SUR SUPPORT SOLIDE
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2010023295A1

  公开（公告）日：2010-03-04

  The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

  本发明涉及一种吡啶哌酸链连接剂及其在有机合成中作为固相连接剂的用途。所述吡啶哌酸固相连接剂可用于将功能基团偶联在一起，这些功能基团可选择为一级胺、二级胺、芳香胺、醇、酚和硫醇。特别地，所述吡啶哌酸固相连接剂可用于肽或伪肽合成，例如反向N到C肽合成或反向逆转肽合成，或用于小有机分子的合成。
• PIPECOLIC LINKER AND ITS USE FOR CHEMISTRY ON SOLID SUPPORT
  申请人：Martinez Jean

  公开号：US20110152464A1

  公开（公告）日：2011-06-23

  The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

  本发明涉及一种肽酪氨酸连接剂及其在有机合成中作为固相连接剂的使用。该肽酪氨酸固相连接剂可用于偶联所选的功能基团，包括一级胺、二级胺、芳香胺、醇、酚和硫醇。特别地，该肽酪氨酸固相连接剂可用于肽或伪肽合成，如反N到C肽合成或反向-反向肽合成，或用于小有机分子的合成。
• NEW SUPPORTED OXIDATION REACTANTS, PROCESS FOR THEIR PREPARATION AND USES THEREOF
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

  公开号：EP2035442A1

  公开（公告）日：2009-03-18
• Supported Oxidation Reactants, Process for their Preparation and Uses Thereof
  申请人：Martinez Jean

  公开号：US20110003943A1

  公开（公告）日：2011-01-06

  The present invention relates to a supported oxidation reactant of formula (I): R-[Met(O) k ] n -X-(I) in which: —R represents a hydrogen atom or an amine function-protecting group, —[Met(O)] represents an oxidized methionine residue of formula—k is 1 or 2—represents a solid or soluble support used in organic synthesis, —X represents a radical derived from a function of the type amine or hydroxyl, or halogeno, capable of anchoring methionine, it being understood that this function capable of anchoring methionine can be separated from the support by means of a functionalized arm or a spacer, and—n is an integer greater than or equal to 1. The invention also relates to the use of a supported oxidation reactant of formula (I), for the formation of intramolecular disulfide bridges, in particular in peptides and/or proteins.
• US8546533B2
  申请人：——

  公开号：US8546533B2

  公开（公告）日：2013-10-01