米氮平半水合物 | 341512-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌嗪氮卓类
• 中文名称: 米氮平半水合物
• 英文名称: Mirtazapine Hemihydrate
• 英文别名: 5-methyl-2,5,19-triazatetracyclo[13.4.0.02,7.08,13]nonadeca-1(15),8,10,12,16,18-hexaene;hydrate
• CAS: 341512-89-8
• 化学式: C34H40N6O
• 分子量: 548.7
• InChiKey: CKQWBUBEACSWKW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.13
• 重原子数：
  41
• 可旋转键数：
  0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  39.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Anhydrous mirtazapine crystals and process for preparing the same
  申请人：Sumika Fine Chemicals Co., Ltd.

  公开号：US20020103372A1

  公开（公告）日：2002-08-01

  Low-hygroscopic anhydrous mirtazapine crystals having a hygroscopic degree of not more than 0.6% by weight when the crystals are stored in the air having a relative humidity of 75% at 25° C. under atmospheric pressure for 500 hours; a process for preparing anhydrous mirtazapine crystals having a hygroscopic degree of not more than 0.6% by weight when the crystals are stored in the air having a relative humidity of 75% at 25° C. under atmospheric pressure for 500 hours, comprising drying crystals of mirtazapine hydrate; a crystal of a mirtazapine hydrate represented by the formula (I): 1 wherein n is an integer of 1 to 5; and a process for preparing crystals of a mirtazapine hydrate, comprising crystallizing a crude mirtazapine using a water-soluble organic solvent and water. The anhydrous mirtazapine crystals can be suitably used, for instance, as an antidepressant.

  低吸湿性无水米氮平晶体，在相对湿度为75%、温度为25℃、大气压下存放500小时时，其吸湿度不超过0.6%。制备无水米氮平晶体的方法，包括干燥米氮平水合物晶体；米氮平水合物晶体的晶体式（I）为：其中n为1至5的整数；制备米氮平水合物晶体的方法，包括使用水溶性有机溶剂和水结晶粗米氮平。这种无水米氮平晶体可以作为抗抑郁药物等用途。
• Orally disintegrating tablet formulations of mirtazapine and process for preparing the same
  申请人：Sanovel Ilac Sanayi ve Ticaret A.S.

  公开号：EP2377522A1

  公开（公告）日：2011-10-19

  The present invention relates to silicon dioxide free orally disintegrating tablet formulations of mirtazapine or a pharmaceutically acceptable salt thereof comprising crospovidone and sodium stearyl fumarate and one or more pharmaceutically acceptable excipient and process for preparing such a formulation.

  本发明涉及米氮平或其药学上可接受的盐的无二氧化硅口腔崩解片剂，该片剂由丙泊维酮和硬脂富马酸钠以及一种或多种药学上可接受的赋形剂组成，还涉及制备这种片剂的工艺。
• Stimulation of appetite and treatment of anorexia in dogs and cats
  申请人：Kindred Biosciences, Inc.

  公开号：US10603272B2

  公开（公告）日：2020-03-31

  Pharmaceutical formulations and methods useful for the treatment of anorexia and the stimulation of appetite and weight gain, and the management of weight loss in dogs and cats.

  用于治疗猫狗厌食症、刺激食欲和体重增加以及控制体重减轻的药物制剂和方法。
• Anhydrous mirtazapine crystals and
  申请人：Sumika Fine Chemicals Co. , Ltd.

  公开号：US20030130504A1

  公开（公告）日：2003-07-10

  Low-hygroscopic anhydrous mirtazapine crystals having a hygroscopic degree of not more than 0.6% by weight when the crystals are stored in the air having a relative humidity of 75% at 25° C. under atmospheric pressure for 500 hours; a process for preparing anhydrous mirtazapine crystals having a hygroscopic degree of not more than 0.6% by weight when the crystals are stored in the air having a relative humidity of 75% at 25° C. under atmospheric pressure for 500 hours, comprising drying crystals of mirtazapine hydrate; a crystal of a mirtazapine hydrate represented by the formula (I): 1 wherein n is an integer of 1 to 5; and a process for preparing crystals of a mirtazapine hydrate, comprising crystallizing a crude mirtazapine using a water-soluble organic solvent and water. The anhydrous mirtazapine crystals can be suitably used, for instance, as an antidepressant.

  低吸湿性无水米氮平晶体，当晶体在大气压下于 25°C、相对湿度为 75%的空气中贮存 500 小时时，其吸湿度不超过 0.6%（按重量计）；一种制备无水米氮平晶体的工艺，当晶体在大气压下于 25°C、相对湿度为 75%的空气中贮存 500 小时时，其吸湿度不超过 0.6%(重量)的无水米氮平晶体的制备方法，包括干燥米氮平水合物晶体；由式(I)表示的米氮平水合物晶体： 1 其中 n 为 1 至 5 的整数；以及一种制备米氮平水合物晶体的工艺，包括使用水溶性有机溶剂和水使粗米氮平结晶。无水米氮平晶体可适当用作抗抑郁剂等。
• ANHYDROUS MIRTAZAPINE CRYSTALS AND PROCESS FOR THE PRODUCTION THEREOF
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1225174B2

  公开（公告）日：2010-06-02