methyl 2-(4-iodophenyl)cyclopropanecarboxylate | 1206629-11-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2-(4-iodophenyl)cyclopropanecarboxylate
• 英文别名: methyl 2-(4-iodophenyl)cyclopropane-1-carboxylate
• CAS: 1206629-11-9
• 化学式: C₁₁H₁₁IO₂
• 分子量: 302.112
• InChiKey: RJKKMVQUEJTUQA-UHFFFAOYSA-N

物化性质

• 沸点：
  315.5±35.0 °C(Predicted)
• 密度：
  1.705±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  methyl 2-(4-iodophenyl)cyclopropanecarboxylate 在 copper(l) iodide 、 sodium tetrachloropalladate(II) 、 四甲基乙二胺 、 potassium carbonate 、 2-二叔丁基膦-1-苯基吲哚 作用下， 以 甲醇 、 水 为溶剂， 反应 1.5h， 生成 methyl 2-(4-ethynylphenyl)cyclopropanecarboxylate
  参考文献：
  名称：

  Identification of a Potent and Selective Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist with Favorable Physicochemical and in Vitro ADME Properties

  摘要：

  The free fatty acid receptor 1 (FFA1, also known as GPR40) enhances glucose-stimulated insulin secretion from pancreatic beta-cells and is recognized as an interesting new target for treatment of type 2 diabetes. Several series of selective FFA1 agonists are already known. Most of these are derived from free fatty acids (FFAs) or glitazones and are relatively lipophilic. Aiming for the development of potent, selective, and less lipophilic FFA1 agonists, the terminal phenyl of a known compound series was replaced by nitrogen containing heterocycles. This resulted in the identification of 37, a selective FFA1 agonist with potent activity on recombinant human FFA1 receptors and on the rat insulinoma cell line INS-1E, optimal lipophilicity, and excellent in vitro permeability and metabolic stability.

  DOI：

  10.1021/jm2005699
• 作为产物：
  描述：

  甲醇 、 trans-2-(4-iodophenyl) cyclopropanecarboxylic acid 在 乙酰氯 作用下， 以97%的产率得到methyl 2-(4-iodophenyl)cyclopropanecarboxylate
  参考文献：
  名称：

  [EN] COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
  [FR] COMPOSÉS DESTINÉS AU TRAITEMENT DE TROUBLES MÉTABOLIQUES

  摘要：

  提供了一种新型化合物，能够调节G蛋白偶联受体GPR40，包括该化合物的组合物和使用方法，用于控制体内胰岛素水平，治疗II型糖尿病、高血压、酮症、肥胖症、葡萄糖不耐受症和与异常高或低血浆脂蛋白、甘油三酯或葡萄糖水平相关的相关疾病。

  公开号：

  WO2010012650A1

文献信息

• SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS AS RXR AGONISTS
  申请人：CONNEXIOS LIFE SCIENCES PVT. LTD.

  公开号：US20160333004A1

  公开（公告）日：2016-11-17

  The present invention relates to certain substituted bicyclic compounds that are agonists of RXR and which are therefore useful in the treatment of certain disorders that can be prevented or treated by activation of this receptor. In addition the invention relates to the compounds, methods for their preparation, pharmaceutical compositions containing the compounds and the uses of these compounds in the treatment of certain disorders.

  本发明涉及某些替代的双环化合物，它们是RXR的激动剂，因此在预防或治疗可以通过激活该受体来预防或治疗的某些疾病的治疗中有用。此外，本发明涉及这些化合物、其制备方法、含有这些化合物的药物组合物以及这些化合物在治疗某些疾病中的用途。
• COMPOUNDS FOR THE TREATMENT OF METABOLIC DISEASES
  申请人：Ulven Trond

  公开号：US20110152315A1

  公开（公告）日：2011-06-23

  There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type I1 diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.

  提供了一种新的化合物，能够调节G蛋白偶联受体GPR40，包括该化合物的组合物以及使用它们的方法，用于控制体内胰岛素水平和治疗诸如2型糖尿病、高血压、酮症酸中毒、肥胖症、葡萄糖耐受性不良以及与异常高或低血浆脂蛋白、甘油三酯或葡萄糖水平有关的相关疾病。
• Compounds for the treatment of metabolic diseases
  申请人：Ulven Trond

  公开号：US08586607B2

  公开（公告）日：2013-11-19

  There is provided novel compounds capable of modulating the G-protein-coupled receptor GPR40, compositions comprising the compounds, and methods for their use for controlling insulin levels in vivo and for the treatment of conditions such as type II diabetes, hypertension, ketoacidosis, obesity, glucose intolerance, and hypercholesterolemia and related disorders associated with abnormally high or low plasma lipoprotein, triglyceride or glucose levels.

  提供了一些新化合物，能够调节G蛋白偶联受体GPR40，包括这些化合物的组合物，以及它们的使用方法，用于控制体内胰岛素水平，治疗诸如II型糖尿病，高血压，酮症，肥胖症，葡萄糖不耐受和与异常高或低的血浆脂蛋白，甘油三酯或葡萄糖水平有关的相关疾病。
• US8586607B2
  申请人：——

  公开号：US8586607B2

  公开（公告）日：2013-11-19
• US9862713B2
  申请人：——

  公开号：US9862713B2

  公开（公告）日：2018-01-09