5-(5-{4-chloro-phenyl}-[1,3,4]oxadiazole-2-yl)-2-fluoro-pyridine | 1022091-41-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-(5-{4-chloro-phenyl}-[1,3,4]oxadiazole-2-yl)-2-fluoro-pyridine
• 英文别名: 2-(4-chlorophenyl)-5-(6-fluoropyridin-3-yl)-1,3,4-oxadiazole
• CAS: 1022091-41-3
• 化学式: C₁₃H₇ClFN₃O
• 分子量: 275.669
• InChiKey: HVCGZNRQZGUQBG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS
  申请人：Dahl Bjarne H.

  公开号：US20100029685A1

  公开（公告）日：2010-02-04

  This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

  本发明涉及氧代噻二唑基和硫代噻二唑基衍生物，发现它们是乙酰胆碱受体的调节剂。由于它们的药理特性，本发明的化合物可能对与中枢神经系统（CNS）和外周神经系统（PNS）的胆碱能系统相关的疾病或障碍，与平滑肌收缩相关的疾病或障碍，内分泌疾病或障碍，神经退行性疾病或障碍，炎症、疼痛以及由于滥用化学物质终止而引起的戒断症状的治疗可能有用。
• TRI-HETEROCYCLIC COMPOUNDS AND A PHARMACEUTICAL COMPRISING THEM AS AN ACTIVE INGREDIENT
  申请人：NAKAI Hisao

  公开号：US20090137604A1

  公开（公告）日：2009-05-28

  Tri-heterocyclic compound of formula (I) wherein each of W, X and Y is carbon or nitrogen; each of U and Z is CR 2 , NR 13 , nitrogen, oxygen, sulfur etc.; A ring is carbocyclic ring, heterocyclic ring; R 1 is alkyl, alkenyl, alkynyl, NR 4 R 5 , OR 6 etc.; R 3 is carbocyclic ring, heterocyclic ring; and a pharmaceutically acceptable salt thereof, a process for the preparation thereof, a pharmaceutical comprising them as an active ingredient. A compound of formula (I) is useful, in order to possess corticotropin releasing factor receptor antagonistic activity, for the prevention and/or treatment of depression, anxiety, eating disorder, posttraumatic stress disorder, peptic ulcer, irritable bowl syndrome, Alzheimer's disease, drug addiction or alcohol dependence syndrome etc.

  公式（I）的三元杂环化合物，其中W、X和Y中的每一个是碳或氮；U和Z中的每一个是CR2、NR13、氮、氧、硫等；一个环是碳环或杂环；R1是烷基、烯基、炔基、NR4R5、OR6等；R3是碳环或杂环；以及其药学上可接受的盐，制备它们的方法，以其为活性成分的制药。公式（I）的化合物在具有促肾上腺皮质激素释放因子受体拮抗活性方面是有用的，用于预防和/或治疗抑郁症、焦虑症、饮食失调、创伤后应激障碍、消化性溃疡、肠易激综合症、阿尔茨海默病、药物成瘾或酒精依赖综合症等。
• US7807688B2
  申请人：——

  公开号：US7807688B2

  公开（公告）日：2010-10-05
• [EN] OXADIAZOLE AND THIADIAZOLE COMPOUNDS AND THEIR USE AS NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS<br/>[FR] COMPOSÉS DE TYPE OXADIAZOLE ET THIADIAZOLE ET LEUR UTILISATION COMME MODULATEURS DES RÉCEPTEURS NICOTINIQUES DE L'ACÉTYLCHOLINE
  申请人：NEUROSEARCH AS

  公开号：WO2008049864A1

  公开（公告）日：2008-05-02

  [EN] This invention relates to oxadiazolyl and thiadiazolyl derivatives, which are found to be modulators of the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
  [FR] L'invention porte sur des dérivés oxadiazolylés et thiadiazolylés, qui sont des modulateurs des récepteurs nicotiniques de l'acétylcholine. En raison de leur profil pharmacologique, les composés de l'invention peuvent être utiles dans le traitement de maladies ou de troubles aussi divers que ceux liés au système cholinergique du système nerveux central (CNS), du système nerveux périphérique (PNS), des maladies ou des troubles liés à la contraction des muscles lisses, des maladies endocriniennes ou les troubles endocriniens, les maladies ou troubles liés à la neurodégénérescence, des maladies ou troubles liés à l'inflammation, de la douleur et des symptômes de sevrage provoqués par l'interruption de l'usage immodéré des substances chimiques.