1-Methyl-3-pyrrolidinyl-α-phenylcyclopentanacetat | 101864-51-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-Methyl-3-pyrrolidinyl-α-phenylcyclopentanacetat
• 英文别名: (1-Methylpyrrolidin-3-yl) 2-cyclopentyl-2-phenylacetate
• CAS: 101864-51-1
• 化学式: C₁₈H₂₅NO₂
• 分子量: 287.402
• InChiKey: BSVKQZZPJPWEPY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESS FOR PRODUCTION OF GLYCOPYRRONIUM TOSYLATE
  申请人：Dermira, Inc.

  公开号：US20210002219A1

  公开（公告）日：2021-01-07

  Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.

  本文提供了生产甲苯磺酸格隆溴铵和甲苯磺酸格隆溴铵组合物的方法。本文还提供了在生产甲苯磺酸格隆溴铵过程中有用的组合物。此外，本文还提供了甲苯磺酸格隆溴铵组合物。甲苯磺酸格隆溴铵可用于治疗多种情况，包括多汗症。
• Process for production of glycopyrronium tosylate
  申请人：Dermira, Inc.

  公开号：US10294201B2

  公开（公告）日：2019-05-21

  Provided herein are methods for the production of glycopyrronium tosylate and glycopyrronium tosylate compositions. Also provided herein are compositions useful in the production of glycopyrronium tosylate. Additionally provided herein are glycopyrronium tosylate compositions. Glycopyrronium tosylate is useful for the treatment of, among other conditions, hyperhidrosis.

  本文提供了生产对甲苯磺酸甘草铵和对甲苯磺酸甘草铵组合物的方法。本文还提供了用于生产对甲苯磺酸甘草铵的组合物。本文还提供了对甲苯磺酸甘草铵组合物。甘草酸铵对甲苯磺酸盐可用于治疗多汗症等疾病。
• Glycopyrrolate salts
  申请人：Dermira, Inc.

  公开号：US10543192B2

  公开（公告）日：2020-01-28

  Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.

  本发明公开了甘草酸盐，包括固体形式和制剂，如外用药。公开了甘草酸盐的制造方法，包括其制剂如外用药，以及用甘草酸盐和其制剂如外用药治疗多汗症的方法。
• GLYCOPYRROLATE SALTS
  申请人：Dermira, Inc.

  公开号：US20200138778A1

  公开（公告）日：2020-05-07

  Salts of glycopyrrolate, including solid forms and formulations such as topicals thereof, are disclosed. Methods of making glycopyrrolate salts, including formulations such as topicals thereof, and methods of treating hyperhidrosis with salts of glycopyrrolate, and formulations such as topicals thereof, are disclosed.