2-Fluoro-4-isopropoxybenzenesulfonyl chloride | 1016734-25-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Fluoro-4-isopropoxybenzenesulfonyl chloride
• 英文别名: 2-fluoro-4-propan-2-yloxybenzenesulfonyl chloride
• CAS: 1016734-25-0
• 化学式: C₉H₁₀ClFO₃S
• 分子量: 252.694
• InChiKey: KCEFRGFQYMDQMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-Fluoro-4-isopropoxybenzenesulfonyl chloride 、 4-chloro-2-(4-piperidyl)-5-[[(3S)-tetrahydropyran-3-yl]methylamino]pyridazin-3-one 在 三乙胺 作用下， 以 乙腈 为溶剂， 以26 %的产率得到4-chloro-2-[1-[2-fluoro-4-(1-methylethoxy)phenyl]sulfonyl-4-piperidyl]-5-[[(3S)-tetrahydropyran-3-yl]methylamino]pyridazin-3-one
  参考文献：
  名称：

  [EN] PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS
  [FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T

  摘要：

  Disclosed herein are oxime compounds having the structure of Formula (I'): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein L1, L2, R1, R2, R3, R4, R7, n, and r are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) and are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. In particular, the compounds are useful for treating viral infections and proliferative disorders, such as cancer.

  公开号：

  WO2023122778A1
• 作为产物：
  描述：

  2-fluoro-4-isopropoxyaniline 在 盐酸 、 sodium nitrite 、 sodium hydrogensulfite 、 copper(l) chloride 、 copper dichloride 作用下， 以 水 、 乙腈 为溶剂， 以67 %的产率得到2-Fluoro-4-isopropoxybenzenesulfonyl chloride
  参考文献：
  名称：

  [EN] PYRIDAZINONE DERIVATIVES USEFUL AS T CELL ACTIVATORS
  [FR] DÉRIVÉS DE PYRIDAZINONE UTILES EN TANT QU'ACTIVATEURS DE LYMPHOCYTES T

  摘要：

  Disclosed herein are oxime compounds having the structure of Formula (I'): or a pharmaceutically acceptable salt, solvate, hydrate, isomer, tautomer, racemate, or isotope thereof, wherein L1, L2, R1, R2, R3, R4, R7, n, and r are as defined herein. Pharmaceutical compositions comprising them, processes for preparing them and uses of them to treat or prevent diseases, disorders and conditions are also provided. The compounds are inhibitors of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ) and are useful in the treatment of diseases, disorders and conditions related to DGKα and / or DGKζ activity. In particular, the compounds are useful for treating viral infections and proliferative disorders, such as cancer.

  公开号：

  WO2023122778A1

文献信息

• US20140275074A1
  申请人：——

  公开号：US20140275074A1

  公开（公告）日：2014-09-18
• US9725442B2
  申请人：——

  公开号：US9725442B2

  公开（公告）日：2017-08-08