2,3-Dichlor-4-methylthiopyridin | 35114-45-5

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,3-Dichlor-4-methylthiopyridin
• 英文别名: 2,3-dichloro-4-methylsulfanyl-pyridine；2,3-Dichloro-4-(methylthio)pyridine；2,3-dichloro-4-methylsulfanylpyridine
• CAS: 35114-45-5
• 化学式: C₆H₅Cl₂NS
• 分子量: 194.084
• InChiKey: WZPIFLAJPMSHMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• [EN] N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2<br/>[FR] COMPOSÉS N-HÉTÉROARYLE SUBSTITUÉS PAR UN N-AZASPIROCYCLOALCANE ET COMPOSITIONS POUR INHIBER L'ACTIVITÉ DE SHP2
  申请人：NOVARTIS AG

  公开号：WO2015107495A1

  公开（公告）日：2015-07-23

  The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

  本发明涉及式I的化合物：其中p、q、Y1、Y2、R1、R2a、R2b、R3a、R3b、R4a、R4b、R5a、R5b、R7和R8在发明摘要中有定义；能够抑制SHP2活性。本发明还提供了一种制备本发明化合物的方法，包括这种化合物的药物制剂以及在管理与SHP2异常活性相关的疾病或疾病中使用这种化合物和组合物的方法。
• [EN] 1 -(TRIAZIN-3-YI_/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE DERIVATIVES AND COMPOSITIONS THEREOF FOR INHIBITING THE ACTIVITY OF SHP2<br/>[FR] DÉRIVÉS DE 1-(TRIAZIN-3-YL/PYRIDAZIN-3-YL)-PIPER(-AZINE)IDINE ET COMPOSITIONS LES CONTENANT POUR L'INHIBITION DE L'ACTIVITÉ DE SHP2
  申请人：NOVARTIS AG

  公开号：WO2015107494A1

  公开（公告）日：2015-07-23

  The present invention relates to compounds of formula I: in which Y1, Y2, Y3, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

  本发明涉及以下式I的化合物：其中Y1、Y2、Y3、R1、R2a、R2b、R3a、R3b、R4a、R4b、R5a、R5b在本发明摘要中有定义；能够抑制SHP2活性。本发明还提供了一种制备本发明化合物的方法，包括含有这种化合物的药物制剂，以及在管理与SHP2异常活性相关的疾病或紊乱的方法中使用这种化合物和组合物。
• SPIRO AROMATIC RING COMPOUND AND APPLICATION THEREOF
  申请人：Etern Biopharma (Shanghai) Co., Ltd.

  公开号：EP3712151A1

  公开（公告）日：2020-09-23

  Provided is a compound of formula I or a pharmaceutically acceptable salt, enantiomer, diastereomer, tautomer, solvate, isotopic substituent, polymorph, prodrug, or metabolite thereof. Also provided is a method for preparing the compound of formula I. The compound of formula I has higher inhibitory activity against SHP2, and thus can be used to prevent or treat a disease related to SHP2.

  本发明提供了一种式 I 的化合物或其药学上可接受的盐、对映体、非对映异构体、同分异构体、溶解物、同位素取代基、多晶型、原药或代谢物。还提供了一种制备式 I 化合物的方法。式I化合物对SHP2具有较高的抑制活性，因此可用于预防或治疗与SHP2相关的疾病。
• [EN] NOVEL CAPSID PROTEIN ASSEMBLY INHIBITOR<br/>[FR] NOUVEL INHIBITEUR D'ASSEMBLAGE DE PROTÉINE CAPSIDIQUE<br/>[ZH] 新型衣壳蛋白装配抑制剂
  申请人：CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD

  公开号：WO2018050110A1

  公开（公告）日：2018-03-22

  本发明属于药物化学领域，涉及一种新型衣壳蛋白装配抑制剂，具体而言，涉及式I所示的化合物、其立体异构体或其药学上可接受的盐、制备方法、药物组合物及医药用途，包括用于治疗受益于衣壳蛋白装配抑制的疾病的用途，尤其是乙型肝炎病毒感染引起的疾病，其中，通式I中A、M、L、D的定义与说明书的定义相同。
• SHP2 PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF
  申请人：Relay Therapeutics, Inc.

  公开号：US20200392161A1

  公开（公告）日：2020-12-17

  The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of SHP2 phosphatase with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with SHP2 deregulation with the compounds and compositions of the disclosure.