2-(2-tolylamino)-2-phenylpropanenitrile | 81512-06-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-tolylamino)-2-phenylpropanenitrile
• 英文别名: 2-(2-Methylanilino)-2-phenylpropanenitrile
• CAS: 81512-06-3
• 化学式: C₁₆H₁₆N₂
• 分子量: 236.316
• InChiKey: AGAGPXFPARIWPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2-tolylamino)-2-phenylpropanenitrile 生成 N-(α-methylbenzylidene)-2-methylaniline
  参考文献：
  名称：

  MAHESHVARI, JITENDRA, M.;SHUKLA, H. K.;THAKER, K. A., J. INST. CHEM., INDIA, 1983, 55, N 2, 83-84

  摘要：

  DOI：
• 作为产物：
  描述：

  苯乙酮 、 邻甲苯胺 以85%的产率得到
  参考文献：
  名称：

  MAHESHVARI, JITENDRA, M.;SHUKLA, H. K.;THAKER, K. A., J. INST. CHEM., INDIA, 1983, 55, N 2, 83-84

  摘要：

  DOI：

文献信息

• Eco-friendly synthesis of α-aminonitriles from ketones in PEG-400 medium using potassium Hexacyanoferrate(II) as cyanide source
  作者：Xiaochun Hu、Yuanhong Ma、Zheng Li

  DOI：10.1016/j.jorganchem.2012.02.005

  日期：2012.5

  An efficient method for the synthesis of α-aminonitriles via one-pot three-component condensation of ketones, amines and potassium hexacyanoferrate(II) using benzoyl chloride as a promoter and PEG-400 as a reaction medium was described. This protocol has the features of use of eco-friendly cyanide source, green reaction medium, high yield, and simple work-up procedure.

  描述了一种通过使用苯甲酰氯作为促进剂和PEG-400作为反应介质的酮，胺和六氰合铁酸钾（II）的一锅式三组分缩合合成α-氨基腈的有效方法。该方案具有使用环保型氰化物源，绿色反应介质，收率高，后处理步骤简单的特点。
• Framework Adaptability and Concerted Structural Response in a Bismuth Metal‐Organic Framework Catalyst.
  作者：Eloy P. Gómez‐Oliveira、Daniel Reinares‐Fisac、Lina M. Aguirre‐Díaz、Fátima Esteban‐Betegón、Mercedes Pintado‐Sierra、Enrique Gutiérrez‐Puebla、Marta Iglesias、M. Ángeles Monge、Felipe Gándara

  DOI：10.1002/anie.202209335

  日期：2022.9.12

  A highly robust bismuth MOF shows an unusual concerted structural response involving changes in inorganic building units upon binding of guest species at different sites. The MOF is an active catalyst for the Strecker reaction.

  高度稳健的铋 MOF 显示出不寻常的一致结构响应，涉及客体物种在不同位点结合时无机结构单元的变化。 MOF 是 Strecker 反应的活性催化剂。
• Shukla; Astik; Thaker, Journal of the Indian Chemical Society, 1981, vol. 58, # 12, p. 1182 - 1182
  作者：Shukla、Astik、Thaker

  DOI：——

  日期：——
• Magnetic Solid Sulfonic Acid Decorated with Hydrophobic Regulators: A Combinatorial and Magnetically Separable Catalyst for the Synthesis of α-Aminonitriles
  作者：Akbar Mobaraki、Barahman Movassagh、Babak Karimi

  DOI：10.1021/co500022g

  日期：2014.7.14

  A three-component, Strecker reaction of a series of aldehydes or ketones, amines, and trimethylsilyl cyanide for the synthesis of alpha-aminonitriles in the presence of a catalytic amount of a magnetic solid sulfonic acid catalyst, Fe3O4@SiO2@Me&Et-PhSO3H under solvent-free conditions have been investigated. This catalyst, with a combination of hydrophobicity and acidity on the Fe3O4@SiO2 core-shell of the magnetic nanobeads, as well as its water-resistant property, enabled easy mass transfer and catalytic activity in the Strecker reaction. The catalyst was easily separated by an external magnet and the recovered catalyst was reused in 6 successive reaction cycles without any significant loss of activity.
• SHUKLA, H. K.;ASTIK, R. R.;THAKER, K. A., J. INDIAN CHEM. SOC., 1981, 58, N 12, 1182
  作者：SHUKLA, H. K.、ASTIK, R. R.、THAKER, K. A.

  DOI：——

  日期：——