3-ethylamino-5-methyl-1-hexanol | 136744-93-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 3-ethylamino-5-methyl-1-hexanol
• 英文别名: 3-(Ethylamino)-5-methylhexan-1-ol
• CAS: 136744-93-9
• 化学式: C₉H₂₁NO
• 分子量: 159.272
• InChiKey: YZPYGKMAMDFIPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  异戊酰氯 在 palladium on activated charcoal 吡啶 、 lithium aluminium tetrahydride 、 ammonium acetate 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 146.5h， 生成 3-ethylamino-5-methyl-1-hexanol
  参考文献：
  名称：

  Enantioselective synthesis of β-amino acids based on BINAP—ruthenium(II) catalyzed hydrogenation

  摘要：

  BINAP-Ru(II) catalyzed hydrogenation of beta-substituted (E)-beta-(acylamino)acrylic acids allows efficient enantioselective synthesis of beta-amino acids. The Z double bond isomers which possess an intramolecular hydrogen bond between amide and ester groups are more reactive but are hydrogenated with poor enantioselectivity. BINAP-Rh(I) complexes afford only moderate stereoselectivity with the opposite sense of enantioselection.

  DOI：

  10.1016/s0957-4166(00)86107-8

文献信息

• Enantioselective synthesis of β-amino acids based on BINAP—ruthenium(II) catalyzed hydrogenation
  作者：William D. Lubell、Masato Kitamura、Ryoji Noyori

  DOI：10.1016/s0957-4166(00)86107-8

  日期：1991.1

  BINAP-Ru(II) catalyzed hydrogenation of beta-substituted (E)-beta-(acylamino)acrylic acids allows efficient enantioselective synthesis of beta-amino acids. The Z double bond isomers which possess an intramolecular hydrogen bond between amide and ester groups are more reactive but are hydrogenated with poor enantioselectivity. BINAP-Rh(I) complexes afford only moderate stereoselectivity with the opposite sense of enantioselection.