4-methyl-2-phenylsulfanyl-1H-imidazole sodium | 403484-86-6

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 4-methyl-2-phenylsulfanyl-1H-imidazole sodium
• CAS: 403484-86-6
• 化学式: C₁₀H₁₀N₂S*Na
• 分子量: 213.259
• InChiKey: DKBXSACKPXBNKD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.49
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  54
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Novel farnesyl protein transferase inhibitors as antitumor agents
  申请人：Schering Corporation

  公开号：US20040122018A1

  公开（公告）日：2004-06-24

  Disclosed are novel tricyclic compounds represented by the formula (1.0): 1 and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.

  揭示了由式（1.0）表示的新型三环化合物： 1 及其药学上可接受的盐或溶剂。这些化合物对于抑制法尼西基蛋白转移酶是有用的。还揭示了包括式1.0化合物的药物组合物。还揭示了使用式1.0化合物治疗癌症的方法。
• Method of treating cancer using FPT inhibitors and antineoplastic agents
  申请人：Schering Corporation

  公开号：US20040006087A1

  公开（公告）日：2004-01-08

  Disclosed is a method of treating cancer in a patient in need of such treatment comprising administering a therapeutically effective amount of an FPT inhibitor and therapeutically effective amounts of one or more antineoplastic agents. Methods of treating non small cell lung cancer, squamous cell cancer of the head and neck, CML, AML, non-Hodgkin's lymphoma and multiple myeloma are disclosed.

  揭示了一种治疗癌症的方法，包括向需要此类治疗的患者施用治疗有效量的FPT抑制剂和治疗有效量的一种或多种抗肿瘤药物。公开了治疗非小细胞肺癌、头颈部鳞状细胞癌、慢性髓细胞白血病、急性髓细胞白血病、非霍奇金淋巴瘤和多发性骨髓瘤的方法。
• TRICYCLIC ANTITUMOR COMPOUNDS BEING FARNESYL PROTEIN TRANSFERASE INHIBITORS
  申请人：SCHERING CORPORATION

  公开号：EP1313725A1

  公开（公告）日：2003-05-28
• USE OF FPT INHIBITORS AND AT LEAST TWO ANTINEOPLASTIC AGENTS IN THE TREATMENT OF CANCER
  申请人：SCHERING CORPORATION

  公开号：EP1453513A1

  公开（公告）日：2004-09-08
• US7342016B2
  申请人：——

  公开号：US7342016B2

  公开（公告）日：2008-03-11