5-[4-(Methylamino)pent-1-en-1-yl]pyridin-3-amine | 312728-33-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-[4-(Methylamino)pent-1-en-1-yl]pyridin-3-amine
• 英文别名: 5-[4-(methylamino)pent-1-enyl]pyridin-3-amine
• CAS: 312728-33-9
• 化学式: C₁₁H₁₇N₃
• 分子量: 191.27
• InChiKey: MZYMTZMLWZPRCD-UHFFFAOYSA-N

物化性质

• 沸点：
  370.1±42.0 °C(Predicted)
• 密度：
  1.035±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  50.9
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Hydroxybenzoate salts of metanicotine compounds
  申请人：Munoz A. Julio

  公开号：US20060122237A1

  公开（公告）日：2006-06-08

  Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

  易感或患有中枢神经系统疾病等状况的患者，通过向需要治疗的患者施用氢氧基苯酸盐型的E-甲基烟碱类化合物来进行治疗。形成E-甲基烟碱化合物的氢氧基苯酸盐也可用于纯化E-甲基烟碱化合物，因为氢氧基苯酸盐倾向于结晶出来，留下杂质，如Z-甲基烟碱化合物和双键迁移的化合物在溶液中。如果需要，氢氧基苯酸盐可以转化为自由基（E-甲基烟碱）或其他药学上可接受的盐形式。
• HYDROXYBENZOATE SALTS OF METANICOTINE COMPOUNDS
  申请人：Dull Gary Maurice

  公开号：US20080249142A1

  公开（公告）日：2008-10-09

  Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine compound) or to another pharmaceutically acceptable salt form.

  易感受或患有中枢神经系统疾病等疾病和疾病的患者，通过给需要治疗的患者施用羟基苯甲酸盐型E-甲烟碱类化合物的组合物来治疗。形成羟基苯甲酸盐的E-甲烟碱化合物也有助于纯化E-甲烟碱化合物，因为羟基苯甲酸盐倾向于结晶出来，留下杂质，例如Z-甲烟碱化合物和双键迁移的化合物在溶液中。如有需要，羟基苯甲酸盐可转化为自由碱（E-甲烟碱化合物）或另一种药学上可接受的盐形式。
• Hydroxybenzoate Salts Of Metanicotine Compounds
  申请人：Munoz Julio A.

  公开号：US20090062321A1

  公开（公告）日：2009-03-05

  Patients susceptible to or suffering from conditions and disorders, such as central nervous system disorders, are treated by administering to a patient in need thereof compositions that are hydroxybenzoate salts of E-metanicotine-type compounds. The formation of hydroxybenzoate salts of the E-metanicotine compounds is also useful in purifying the E-metanicotine compounds, as the hydroxybenzoate salts tend to crystallize out, leaving impurities such as Z-metanicotine compounds, and compounds where the double bond has migrated, in solution. If desired, the hydroxybenzoate salts can be converted to either the free base (the E-metanicotine) or to another pharmaceutically acceptable salt form.

  对于易感受或患有中枢神经系统疾病等疾病和疾病的患者，可以通过向需要治疗的患者施用羟基苯甲酸酯盐的E-甲烟碱型化合物来进行治疗。羟基苯甲酸酯盐的形成对于纯化E-甲烟碱化合物也是有用的，因为羟基苯甲酸酯盐往往会结晶出来，留下杂质，例如Z-甲烟碱化合物和双键迁移的化合物。如果需要，羟基苯甲酸酯盐可以转化为自由碱基（E-甲烟碱）或其他药学上可接受的盐形式。
• US7459469B2
  申请人：——

  公开号：US7459469B2

  公开（公告）日：2008-12-02
• US8053451B2
  申请人：——

  公开号：US8053451B2

  公开（公告）日：2011-11-08