2-chloro-N-[[4-[[(2-chlorobenzoyl)amino]methyl]cyclohexyl]methyl]benzamide | 34453-78-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-N-[[4-[[(2-chlorobenzoyl)amino]methyl]cyclohexyl]methyl]benzamide
• CAS: 34453-78-6
• 化学式: C₂₂H₂₄Cl₂N₂O₂
• 分子量: 419.351
• InChiKey: KGEMPBILHDGZDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Methods for Determining the Oncogenic Condition of Cell, Uses Thereof, and Methods for Treating Cancer
  申请人：INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)

  公开号：US20170176446A1

  公开（公告）日：2017-06-22

  The invention relates to methods for detecting the oncogenic condition of cells, including step where the amount of the OCDO compound in said cells is measured, and to the uses thereof. The invention further relates to OCDO inhibitors for use in methods for treating cancer.

  这项发明涉及检测细胞的致癌状态的方法，包括测量所述细胞中OCDO化合物的数量的步骤，以及其用途。该发明还涉及用于治疗癌症方法中使用的OCDO抑制剂。
• METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER
  申请人：De Medina Philippe

  公开号：US20120100124A1

  公开（公告）日：2012-04-26

  The invention relates to methods for detecting the oncogenic condition of cells, including step where the amount of the OCDO compound in said cells is measured, and to the uses thereof. The invention further relates to OCDO inhibitors for use in methods for treating cancer.

  本发明涉及用于检测细胞的致癌状态的方法，其中包括测量所述细胞中OCDO化合物的量的步骤，并涉及其用途。本发明还涉及用于治疗癌症的OCDO抑制剂的使用方法。
• MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER
  申请人：INSERM (Institut National de la Santé et de la Recherche Médicale)

  公开号：EP2446276A1

  公开（公告）日：2012-05-02
• [EN] BINARY COMPOSITIONS COMPRISING AN NO-DONOR AND AN A-SMASE INHIBITOR FOR THE TREATMENT OF RESPIRATORY DISEASES<br/>[FR] COMPOSITIONS BINAIRES COMPRENANT UN DONNEUR D'OXYDE NITRIQUE ET UN INHIBITEUR DE L'A-SMASE, SERVANT AU TRAITEMENT DE MALADIES RESPIRATOIRES
  申请人：PHARMAPATENTS GLOBAL LTD

  公开号：WO2010035047A1

  公开（公告）日：2010-04-01

  The present invention relates to a pharmaceutical composition comprising an A-SMase inhibitor and/or a NO-donor. Preferred A-SMase inhibitors are tricyclic antidepressants, most preferably amitriptyline. A preferred NO-donor is arginine. Preferably the pharmaceutical composition comprises an A-SMase inhibitor and a NO-donor, which preferably act synergistically to inhibit A-SMase. The pharmaceutical composition is suitable for treating or preventing respiratory disorders such as chronic cough, cystic fibrosis, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis and emphysema. Preferably the pharmaceutical composition is administered by inhalation. The present invention also relates to methods of treating or preventing respiratory disorders, methods of inhibiting A-SMase, and assays for investigating the effect of test compounds upon A-SMase activity in vitro.
• [EN] METHODS FOR DETERMINING THE ONCOGENIC CONDITION OF CELL, USES THEREOF, AND METHODS FOR TREATING CANCER<br/>[FR] MÉTHODES POUR DÉTERMINER L'ÉTAT ONCOGÉNIQUE D'UNE CELLULE, LEURS APPLICATIONS, ET MÉTHODES POUR TRAITER LE CANCER
  申请人：INST NAT SANTE RECH MED

  公开号：WO2010149941A1

  公开（公告）日：2010-12-29

  L'invention concerne des méthodes pour détecter l'état oncogénique de cellules comprenant une étape où l'on mesure la quantité du composé OCDO dans lesdites cellules, et leurs applications. L'invention concerne aussi des inhibiteurs d'OCDO pour utilisation dans des méthodes de traitement du cancer.