3-Pyridine propionyl chloride | 1100857-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-Pyridine propionyl chloride
• 英文别名: 2-Pyridin-3-ylpropanoyl chloride
• CAS: 1100857-14-4
• 化学式: C₈H₈ClNO
• 分子量: 169.611
• InChiKey: GGSOTRFMNYCCJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Piperidinyloxy and pyrrolidinyloxy oxazolidinone antibacterials
  申请人：——

  公开号：US20020103377A1

  公开（公告）日：2002-08-01

  Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula: 1 wherein R 1 is a piperidinyl, pyrrolidinyl or azetidinyl moiety as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

  Piperidinyloxy、pyrrolidinyloxyl和azetidinyloxy化合物的公式如下：其中R1是如本文和描述中所述的哌啶基、吡咯基或氮杂环丙基，并且其中取代基具有描述中所指示的含义。这些化合物可用作抗菌剂。
• [EN] SULFONYLQUINOXALONE ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ ANTAGONISTS<br/>[FR] DERIVES D'ACETAMIDE SULFONYLQUINOXALONE ET COMPOSES ASSOCIES EN TANT QU'ANTAGONISTES DE LA BRADYKININE
  申请人：ELAN PHARM INC

  公开号：WO2003093245A1

  公开（公告）日：2003-11-13

  Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists to relieve symptons, associated with bradykinin including pain, inflammation, bronchoconstriction, cerebral edema, etc.

  揭示了作为布雷金肽拮抗剂有用的磺酰基喹诺酮乙酰胺衍生物，可用于缓解与布雷金肽相关的症状，包括疼痛、炎症、支气管收缩、脑水肿等。
• Process for preparing acetonides
  申请人：——

  公开号：US20020132837A1

  公开（公告）日：2002-09-19

  Acetonides are obtained in a one-step reaction of a carboxylic acid halide, a 1,2-aminoalcohol, and 2-alkoxypropene or 2,2-dialkoxypropane in an ether solvent and in the presence of an inorganic base. Acetonides are also obtained in a two-step reaction scheme in which an acid halide and 1,2-aminoalcohol are reacted in an ether solvent in the presence of LiOH to form a hydroxyamide, which is then reacted with 2-alkoxypropene or 2,2-dialkoxypropane in the presence of acid to form the acetonide. The acetonides resulting from the one-step and two-step protocols can be further reacted with an allylating agent such as an allyl halide in the presence of a strong base to provide the corresponding allyl acetonide. The acetonides and allyl acetonides can serve as intermediates in the production of certain HIV protease inhibitors which are useful for treating HIV infection and AIDS.

  Acetonides是通过在醚溶剂中，在无机碱的存在下，将羧酸卤、1,2-氨基醇和2-烷氧基丙烯或2,2-二烷氧基丙烷进行一步反应而获得的。Acetonides也可以通过两步反应方案获得，其中酸卤和1,2-氨基醇在醚溶剂中在LiOH的存在下反应以形成羟基酰胺，然后在酸的存在下与2-烷氧基丙烯或2,2-二烷氧基丙烷反应以形成缩醛。通过一步和两步方案得到的缩醛可以进一步与烯丙基卤等烯丙基化试剂在强碱的存在下反应，从而得到相应的烯丙基缩醛。这些缩醛和烯丙基缩醛可以作为某些用于治疗HIV感染和艾滋病的HIV蛋白酶抑制剂的生产中间体。
• [EN] PIPERIDINYLOXY AND PYRROLIDINYLOXYPHENYL OXAZOLIDINONES AS ANTIBACTERIALS<br/>[FR] PIPERIDINYLOXY ET PYRROLIDINYLOXYPHENYL OXAZOLIDINONES A ACTIVITE ANTIBACTERIENNE
  申请人：ORTHO MCNEIL PHARM INC

  公开号：WO2001046164A1

  公开（公告）日：2001-06-28

  Piperidinyloxy, pyrrolidinyloxyl and azetidinyloxy compounds of the formula (I): wherein R1 is a piperidinyl, pyrrolidinyl or azetidinyl moiety as described herein and in which the substituents have the meaning indicated in the description. These compounds are useful as antibacterial agents.

  Piperidinyloxy，pyrrolidinyloxyl和azetidinyloxy化合物的化学式（I）：其中R1是piperidinyl，pyrrolidinyl或azetidinyl基团，如本文所述，并且其中的取代基具有所述描述中指示的含义。这些化合物可用作抗菌剂。
• Sulfonylquinoxalone acetamide derivatives as bradykinin antagonists
  申请人：——

  公开号：US20040147519A1

  公开（公告）日：2004-07-29

  Disclosed are sulfonylquinoxalone acetamide derivatives useful as bradykinin antagonists.

  本发明涉及一种作为Bradykinin拮抗剂有用的磺酰基喹喔啉乙酰胺衍生物。