5-异丙基-6-甲基-2(1H)-吡啶酮 | 102440-00-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 5-异丙基-6-甲基-2(1H)-吡啶酮
• 英文名称: 2-Oxo-6-methyl-5-isopropyl-1,2-dihydro-pyridin
• 英文别名: 5-isopropyl-6-methyl-1H-pyridin-2-one；6-methyl-5-propan-2-yl-1H-pyridin-2-one
• CAS: 102440-00-6
• 化学式: C₉H₁₃NO
• 分子量: 151.208
• InChiKey: VHRARNHNSCLJRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• [EN] COT MODULATORS AND METHODS OF USE THEREOF<br/>[FR] MODULATEURS DE COT ET PROCÉDÉS D'UTILISATION ASSOCIÉS
  申请人：GILEAD SCIENCES INC

  公开号：WO2017007689A1

  公开（公告）日：2017-01-12

  The present disclosure relates generally to modulators of Cot (cancer Osaka thyroid) and methods of use and manufacture thereof.

  本公开涉及通常与Cot（大阪甲状腺癌）调节剂及其使用和制造方法。
• Modified Nucleobases with Uniform H-Bonding Interactions, Homo- and Hetero-Basepair Bias, and Mismatch Discrimination
  申请人：Carnegie Mellon University

  公开号：US20210230680A1

  公开（公告）日：2021-07-29

  Described herein are divalent nucleobases that each binds two nucleic acid strands, matched or mismatched when incorporated into a nucleic acid or nucleic acid analog backbone, such as in a γ-peptide nucleic acid (γPNA). Also provided are genetic recognition reagents comprising one or more of the divalent nucleobases and a nucleic acid or nucleic acid analog backbone, such as a γPNA backbone. Uses for the divalent nucleobases and monomers and genetic recognition reagents containing the divalent nucleobases also are provided.

  本文描述了二价核碱基，当它们被并入核酸或核酸类似物骨架（例如γ-肽核酸（γPNA））中时，每个核碱基可以结合两条核酸链，无论匹配或不匹配。此外，还提供了包含一个或多个二价核碱基和核酸或核酸类似物骨架（例如γPNA骨架）的基因识别试剂。还提供了包含二价核碱基的单体和基因识别试剂的用途。
• [EN] TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4<br/>[FR] LIGANDS TRICYCLIQUES POUR LA DÉGRADATION D'IKZF2 OU D'IKZF4
  申请人：C4 THERAPEUTICS INC

  公开号：WO2022081925A1

  公开（公告）日：2022-04-21

  Tricyclic compounds that degrade IKZF2 and/or IKZF4 are provided for medical therapy, including abnormal cellular proliferation, including cancer, inflammatory disorders, neurodegenerative disorders or autoimmune disorders.

  提供了降解IKZF2和/或IKZF4的三环化合物，用于医疗治疗，包括异常细胞增殖，包括癌症、炎症性疾病、神经退行性疾病或自身免疫性疾病。
• [EN] NITROGEN CONTAINING 2,3-DIHYDROQUINAZOLINONE COMPOUNDS AS NAV1.8 INHIBITORS<br/>[FR] COMPOSÉS 2,3-DIHYDROQUINAZOLINE CONTENANT DE L'AZOTE SERVANT D'INHIBITEURS DE NAV1.8
  申请人：GLAXOSMITHKLINE IP DEV LTD

  公开号：WO2022129281A1

  公开（公告）日：2022-06-23

  Compounds of formula (I) are described, wherein each of the variable groups is as defined in the specification. Also described are pharmaceutical compositions containing a compound of formula (I), and uses of the compounds and pharmaceutical compositions for inhibiting Nav1.8 voltage-gated sodium channels and treating Nav1.8 mediated diseases, disorders, and conditions, such as pain and pain-associated diseases, disorders, and conditions and cardiovascular diseases, disorders, and conditions, such as atrial fibrillation.

  本文描述了公式(I)的化合物，其中每个变量组的定义如规范中所述。还描述了含有公式(I)化合物的制药组合物，以及使用这些化合物和制药组合物来抑制Nav1.8电压门控钠通道并治疗Nav1.8介导的疾病、障碍和病症，如疼痛和与疼痛相关的疾病、障碍和病症以及心血管疾病、障碍和病症，如心房颤动。
• 1,3-OXAZOLIDIN-2-ONE DERIVATIVES USEEFUL AS CETP INHIBITORS
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2029560B1

  公开（公告）日：2013-04-24