1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane | 13348-33-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane
• 英文别名: 1-(Difluoromethyl)-4-[2-[4-(difluoromethyl)phenyl]-1,1,2,2-tetrafluoroethyl]benzene
• CAS: 13348-33-9
• 化学式: C₁₆H₁₀F₈
• 分子量: 354.243
• InChiKey: FYGCSPKCNLXJOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 四氯化碳 为溶剂， 反应 30.0h， 以81%的产率得到1,2-bis<4-(bromodifluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane
  参考文献：
  名称：

  New synthesis of octafluoro[2.2]paracyclophane

  摘要：

  A new synthesis of 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane (2) is reported. Easy preparation of gram quantities of 2 is accomplished by treatment of alpha,alpha'-dibromo-alpha,alpha,alpha',alpha'-tetrafluoroxylene with a complex low-valent form of Ti which is made by reduction of TiCl4 with equimolar quantities of LiAlH4 in THF. Use of high-dilution techniques is required for the reaction to be successful. The formation of 2 is believed to proceed via the reactive monomeric species alpha,alpha,alpha',alpha'-tetrafluoro-p-xylylene (4).

  DOI：

  10.1021/jo00059a038
• 作为产物：
  描述：

  4,4-二甲基苯甲酸 在 吡啶 、 chromium(VI) oxide 、 盐酸 、 二乙胺基三氟化硫 、 硫酸 、 copper(II) sulfate 、 溶剂黄146 作用下， 以 四氢呋喃 、 水 、 苯 为溶剂， 反应 24.0h， 生成 1,2-bis<4-(difluoromethyl)phenyl>-1,1,2,2-tetrafluoroethane
  参考文献：
  名称：

  New synthesis of octafluoro[2.2]paracyclophane

  摘要：

  A new synthesis of 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane (2) is reported. Easy preparation of gram quantities of 2 is accomplished by treatment of alpha,alpha'-dibromo-alpha,alpha,alpha',alpha'-tetrafluoroxylene with a complex low-valent form of Ti which is made by reduction of TiCl4 with equimolar quantities of LiAlH4 in THF. Use of high-dilution techniques is required for the reaction to be successful. The formation of 2 is believed to proceed via the reactive monomeric species alpha,alpha,alpha',alpha'-tetrafluoro-p-xylylene (4).

  DOI：

  10.1021/jo00059a038

文献信息

• New synthesis of octafluoro[2.2]paracyclophane
  作者：William R. Dolbier、Mohammed Ali Asghar、He Qi Pan、Lech Celewicz

  DOI：10.1021/jo00059a038

  日期：1993.3

  A new synthesis of 1,1,2,2,9,9,10,10-octafluoro[2.2]paracyclophane (2) is reported. Easy preparation of gram quantities of 2 is accomplished by treatment of alpha,alpha'-dibromo-alpha,alpha,alpha',alpha'-tetrafluoroxylene with a complex low-valent form of Ti which is made by reduction of TiCl4 with equimolar quantities of LiAlH4 in THF. Use of high-dilution techniques is required for the reaction to be successful. The formation of 2 is believed to proceed via the reactive monomeric species alpha,alpha,alpha',alpha'-tetrafluoro-p-xylylene (4).