(2S)-2-tert-butoxy-2-(2-(2-(1,3-dioxoisoindolin-2-yl)acetamido)-7-(8-fluoro-5-methylchroman-6-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetic acid | 1454611-34-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: (2S)-2-tert-butoxy-2-(2-(2-(1,3-dioxoisoindolin-2-yl)acetamido)-7-(8-fluoro-5-methylchroman-6-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetic acid
• 英文别名: (2S)-2-[2-[[2-(1,3-dioxoisoindol-2-yl)acetyl]amino]-7-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
• CAS: 1454611-34-7
• 化学式: C₃₃H₃₂FN₅O₇
• 分子量: 629.645
• InChiKey: PJSDGUPLUWNHSS-LJAQVGFWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  46
• 可旋转键数：
  8
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• Inhibitors of Human Immunodeficiency Virus Replication
  申请人：BRISTOL-MYERS SQUIBB COMPANY

  公开号：US20130237499A1

  公开（公告）日：2013-09-12

  The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection.

  该披露通常涉及到公式I的化合物，包括用于治疗人类免疫缺陷病毒（HIV）感染的组合物和方法。该披露提供了HIV的新型抑制剂，包含这些化合物的药物组合物，以及使用这些化合物治疗HIV感染的方法。
• INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION
  申请人：Bristol-Myers Squibb Company

  公开号：EP2822950A1

  公开（公告）日：2015-01-14
• US9006235B2
  申请人：——

  公开号：US9006235B2

  公开（公告）日：2015-04-14
• [EN] INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION<br/>[FR] INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'IMMUNODÉFICIENCE HUMAINE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2013134142A1

  公开（公告）日：2013-09-12

  The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection. (i)