6-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine | 1262618-69-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-[4-(pentafluoro-lambda~6~-sulfanyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine
• 英文别名: 6-[4-(pentafluoro-λ6-sulfanyl)phenyl]-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyridine；Pentafluoro-[4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]-lambda6-sulfane；pentafluoro-[4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl]phenyl]-λ6-sulfane
• CAS: 1262618-69-8
• 化学式: C₁₃H₇F₈N₃S
• 分子量: 389.272
• InChiKey: OKOGSMXJOCMRCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  25
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  31.2
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS
  申请人：Gilead Palo Alto, Inc.

  公开号：EP2464645A1

  公开（公告）日：2012-06-20
• US8754103B2
  申请人：——

  公开号：US8754103B2

  公开（公告）日：2014-06-17
• US8952034B2
  申请人：——

  公开号：US8952034B2

  公开（公告）日：2015-02-10
• [EN] FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS<br/>[FR] COMPOSÉS HÉTÉROCYCLIQUES CONDENSÉS EN TANT QUE MODULATEURS DE CANAUX IONIQUES
  申请人：GILEAD PALO ALTO INC

  公开号：WO2011014462A1

  公开（公告）日：2011-02-03

  The present invention relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein W1. W2, W3 R1, Q, X1, X2 and X3 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.