4-[2-[N-(tert-Butoxycarbonyl)-N-[(2R)-2-(5-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl trifluoromethanesulfonate | 643093-94-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-[2-[N-(tert-Butoxycarbonyl)-N-[(2R)-2-(5-chloro-3-pyridyl)-2-hydroxyethyl]amino]ethyl]phenyl trifluoromethanesulfonate
• 英文别名: 4-[2-[N-(tert-Butoxycarbonyl)-N-[(2R)-2-(5-chloro-pyridin-3-yl)-2-hydroxyethyl]amino]ethyl]phenyl trifluoromethanesulfonate；[4-[2-[[(2R)-2-(5-chloropyridin-3-yl)-2-hydroxyethyl]-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethyl]phenyl] trifluoromethanesulfonate
• CAS: 643093-94-1
• 化学式: C₂₁H₂₄ClF₃N₂O₆S
• 分子量: 524.946
• InChiKey: QSBOGDOGMYIZFA-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  34
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  114
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Aminoalcohol derivatives
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：US20040006143A1

  公开（公告）日：2004-01-08

  The present invention relates to a compound formula [I]: 1 wherein 2 Y is bond, —O—(CH 2 ) n — (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R 1 is hydrogen, lower alkyl, etc., R 2 is hydrogen or an amino protective group, R 3 is hydrogen or lower alkyl, R 4 is hydrogen or lower alkyl, R 5 and R 8 are each independently hydrogen, halogen, hydroxy, lower alkyl, etc., R 6 is hydrogen, lower alkyl, etc., R 9 is hydrogen or lower alkyl, and i is 1 or 2, or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.

  本发明涉及一种化合物公式[I]: 1 其中 2 Y是键，—O—(CH 2 ) n — (其中n是1、2、3或4)，等等， Z是氰基，四唑基，等等， R 1 是氢，低级烷基，等等， R 2 是氢或氨基保护基团， R 3 是氢或低级烷基， R 4 是氢或低级烷基， R 5 和R 8 各自独立是氢，卤素，羟基，低级烷基，等等， R 6 是氢，低级烷基，等等， R 9 是氢或低级烷基，以及 i是1或2， 或其盐。本发明的化合物[I]及其药用可接受的盐对于预防性和/或治疗性治疗尿频或尿失禁是有用的。
• AMINOALCOHOL DERIVATIVES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1546086A2

  公开（公告）日：2005-06-29
• US7037938B2
  申请人：——

  公开号：US7037938B2

  公开（公告）日：2006-05-02
• US7629366B2
  申请人：——

  公开号：US7629366B2

  公开（公告）日：2009-12-08
• [EN] AMINOALCOHOL DERIVATIVES<br/>[FR] DERIVES D'AMINOALCOOL
  申请人：FUJISAWA PHARMACEUTICAL CO

  公开号：WO2004002939A2

  公开（公告）日：2004-01-08

  The present invention relates to a compound formula [I]: Y is bond, -0-(CH2)n- (in which n is 1, 2, 3 or 4), etc., Z is cyano, tetrazolyl, etc., R1 is hydrogen, lower alkyl, etc., R2 is hydrogen or an amino protective group, R3 is hydrogen or lower alkyl, R4 is hydrogen or lower alkyl,R5 and R8 are each independently hydrogen, halogen, hydroxy,lower alkyl, etc., R6 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, and i is 1 or 2,or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of pollakiurea or urinary incontinence.