2-[6-[[Amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydroiodide | 72099-47-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[6-[[Amino-[[amino-(4-chloroanilino)methylidene]amino]methylidene]amino]hexyl]-1-[amino-(4-chloroanilino)methylidene]guanidine;dihydroiodide
• CAS: 72099-47-9
• 化学式: C22H32Cl2I2N10
• 分子量: 761.3
• InChiKey: SAJLOWXGFQHFEJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.136
• 重原子数：
  36
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  178
• 氢给体数：
  8
• 氢受体数：
  2

文献信息

• Triclosan containing medical devices
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP1273313A2

  公开（公告）日：2003-01-08

  The present invention relates to polymeric medical articles comprising the antiinfective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of antiinfective agent, for example into the bloodstream of a subject.

  本发明涉及含有抗感染药剂洗必泰和三氯生的聚合物医疗用品。本发明至少部分基于以下发现：这些化合物之间的协同关系允许使用相对较低水平的两种制剂，并且发现当这些化合物包含在亲水性或疏水性聚合物中时，可以实现有效的抗菌活性。此外，本发明还发现无氯己定碱和三氯生一起使用时，能更有效地融入聚合物医疗用品中。根据本发明制备的医疗用品具有预防或抑制感染的优点，同时避免了抗感染剂的过高释放，例如释放到受试者的血液中。
• Improved cleaning composition
  申请人：The Clorox Company

  公开号：EP2256182A2

  公开（公告）日：2010-12-01

  An improved cleaning composition adapted to clean a variety of hard surfaces. The improved cleaning composition includes a cationic biocide that includes biguanide compounds and/or quats.

  一种适用于清洁各种硬表面的改良清洁组合物。改进后的清洁组合物包括一种阳离子杀菌剂，其中包括双胍化合物和/或季铵盐。
• Methods for increasing effectiveness of antimicrobial agents in polymeric films
  申请人：AVERY DENNISON CORPORATION

  公开号：EP2649878A1

  公开（公告）日：2013-10-16

  The application relates: to multilayered polymeric films comprising a first skin layer comprising at least one gas and vapor barrier organic polymer, a core layer that comprises at least one elastomeric organic polymer, and a second skin layer that comprises at least one sealable organic polymer and at least one antimicrobial agent; to articles comprising the film useful in various applications such as medical and health care applications and to a method of providing a gas and vapor barrier with antimicrobial activity to an article comprising manufacturing an article comprising said film.

  该申请涉及：多层聚合物薄膜，包括由至少一种气体和蒸汽阻隔有机聚合物组成的第一表皮层、由至少一种弹性有机聚合物组成的芯层以及由至少一种可密封有机聚合物和至少一种抗菌剂组成的第二表皮层；包括在医疗和保健等各种应用中有用的薄膜的物品，以及为物品提供具有抗菌活性的气体和蒸汽阻隔层的方法，包括制造包括所述薄膜的物品。
• Non-fouling, anti-microbial, anti-thrombogenic graft compositions
  申请人：ARROW INTERNATIONAL, INC.

  公开号：US10016532B2

  公开（公告）日：2018-07-10

  The present invention generally relates to articles of manufacture, such as medical devices, having a non-fouling surface comprising a grafted polymer material. The surface resists the adhesion of biological material.

  本发明一般涉及制造物品，如医疗器械，其表面由接枝聚合物材料构成，具有防污功能。该表面可防止生物材料附着。
• Non-fouling, anti-microbial, anti-thrombogenic graft-from compositions
  申请人：ARROW INTERNATIONAL, INC.

  公开号：US10117974B2

  公开（公告）日：2018-11-06

  A method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, the substrate surface and the grafted polymer layer, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2 in a fibrinogen binding assay in which the modified surface is incubated for 60 minutes at 37° C. in 70 μg/mL fibrinogen derived from human plasma containing 1.4 μg/mL I-125 radiolabeled fibrinogen.

  一种制备和产生制造品的方法，包括具有表面的基底、表面下的块体和基底表面上的接枝聚合物层，基底表面和接枝聚合物层共同构成改性表面，在纤维蛋白原结合试验中，改性表面的纤维蛋白原吸附量小于约 125 ng/cm2。在含有 1.4 μg/mL I-125 放射性标记纤维蛋白原的 70 μg/mL 源自人血浆的纤维蛋白原中。