2-(3-Methylbenzyl)-1-methylpyrrolidin | 66162-91-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-Methylbenzyl)-1-methylpyrrolidin
• 英文别名: 2-(3-methylbenzyl)-1-methylpyrrolidine；1-methyl-2-[(3-methylphenyl)methyl]pyrrolidine
• CAS: 66162-91-2
• 化学式: C₁₃H₁₉N
• 分子量: 189.301
• InChiKey: JJXZCWHSFVUTRO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,2-二乙氧基-1-甲基吡咯烷 、 3-甲基苄基氯 在 ammonium chloride 、 magnesium 作用下， 以 乙醚 为溶剂， 生成 2-(3-Methylbenzyl)-1-methylpyrrolidin
  参考文献：
  名称：

  2-(Nuclearly-substituted)benzylpyrrolidines

  摘要：

  2-苄基吡咯烷酮在苄基环上带有1至4个核取代基，具有药理活性，特别是对于中枢神经系统、血压和对于温血动物的疼痛感觉。它们可以通过还原适当的2-苄基吡咯烷酮合成，并根据已建立的传统技术制成药物组合物。

  公开号：

  US04279918A1

文献信息

• AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF
  申请人：Sugasawa Keizo

  公开号：US20100249088A1

  公开（公告）日：2010-09-30

  [Object] To provide a therapeutic and/or prophylactic agent for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, based on an excellent trkA receptor inhibitory action. [Means for Solution] A novel azolecarboxamide compound in which a thiazole ring or an oxazole ring is bonded to a benzene ring, a pyridine ring, a pyridazine ring, a thiophene ring, a pyrazole ring or a pyrrole ring through carboxamide, or a salt thereof is confirmed to have a potent trkA receptor inhibitory activity, and found to be capable of being used as a therapeutic and/or prophylactic agent which is excellent in efficacy and safety for urinary frequency, urinary urgency, and urinary incontinence associated with various lower urinary tract diseases including overactive bladder, various lower urinary tract diseases accompanied by lower urinary tract pain, such as interstitial cystitis, chronic prostatitis, and the like, and various diseases accompanied by pain, thereby completing the present invention.

  [目的] 提供一种治疗和/或预防下尿道疾病引起的尿频、尿急和尿失禁的治疗剂和/或预防剂，包括膀胱过度活动、伴有下尿道疼痛的各种下尿道疾病，如间质性膀胱炎、慢性前列腺炎等，以及伴有疼痛的各种疾病，基于出色的trkA受体抑制作用。 [解决方案] 发现一种新型的唑类羧酰胺化合物，其中一种噻唑环或噁唑环通过羧酰胺键与苯环、吡啶环、吡嗪环、噻吩环、吡唑环或吡咯环结合，或其盐具有强效的trkA受体抑制活性，并发现它能够被用作治疗和/或预防剂，对于包括膀胱过度活动、伴有下尿道疼痛的各种下尿道疾病，如间质性膀胱炎、慢性前列腺炎等，以及伴有疼痛的各种疾病，具有出色的疗效和安全性，从而完成了本发明。
• US4279918A
  申请人：——

  公开号：US4279918A

  公开（公告）日：1981-07-21
• US8304547B2
  申请人：——

  公开号：US8304547B2

  公开（公告）日：2012-11-06
• 2-(Nuclearly-substituted)benzylpyrrolidines
  申请人：Byk Gulden Lomberg Chemische Fabrik G.m.b.H.

  公开号：US04279918A1

  公开（公告）日：1981-07-21

  2-Benzylpyrrolidines bearing from 1 to 4 nuclear substituents on the benzyl ring are pharmacologically active, particularly on the CNS, on blood pressure and on pain sensation for warm-blooded animals. They are synthesized, e.g., by reducing appropriate 2-benzylpyrrolidines and are formulated into medicament compositions according to established conventional techniques.

  2-苄基吡咯烷酮在苄基环上带有1至4个核取代基，具有药理活性，特别是对于中枢神经系统、血压和对于温血动物的疼痛感觉。它们可以通过还原适当的2-苄基吡咯烷酮合成，并根据已建立的传统技术制成药物组合物。