3-methyl-1-(4-(2-oxo-8-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)-3-phenylpyrrolidine-2,5-dione | 1349711-20-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 3-methyl-1-(4-(2-oxo-8-propyl-4-(trifluoromethyl)-2H-chromen-7-yloxy)butyl)-3-phenylpyrrolidine-2,5-dione
• 英文别名: 3-Methyl-1-[4-[2-oxo-8-propyl-4-(trifluoromethyl)chromen-7-yl]oxybutyl]-3-phenylpyrrolidine-2,5-dione
• CAS: 1349711-20-1
• 化学式: C₂₈H₂₈F₃NO₅
• 分子量: 515.529
• InChiKey: FJRKHHWUMBSTIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• 2-OXOCHROMENE DERIVATIVES
  申请人：OKUDA Ayumu

  公开号：US20090286780A1

  公开（公告）日：2009-11-19

  To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. [Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

  提供一种新型的LXRβ激动剂，可用作预防和/或治疗动脉粥样硬化；动脉硬化，如糖尿病引起的动脉硬化；血脂异常；高胆固醇血症；与脂质相关的疾病；由炎性细胞因子引起的炎症性疾病；皮肤疾病，如过敏性皮肤病；糖尿病；或阿尔茨海默病。[解决方法]由下面的一般式（1）所表示的2-氧代色素衍生物或其盐，或它们的溶剂化合物。
• 2-OXOCHROMENE DERIVATIVE
  申请人：Kowa Company, Ltd.

  公开号：EP2248811A1

  公开（公告）日：2010-11-10

  [Object] It is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes;dyslipidemia; hypercholesterolemia; lipid-reflated diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

  目的 提供一种新型LXRβ激动剂，该激动剂可作为动脉粥样硬化、动脉硬化（如糖尿病引起的动脉硬化）、血脂异常、高胆固醇血症、血脂膨胀性疾病、由炎症细胞因子引起的炎症性疾病、皮肤病（如过敏性皮肤病）、糖尿病或阿尔茨海默病的预防和/或治疗药物。由以下通式（1）代表的 2-氧代二氢苯衍生物或其盐，或它们的溶解物。
• US7919509B2
  申请人：——

  公开号：US7919509B2

  公开（公告）日：2011-04-05