4-allyl-2,3-dimethoxyphenol | 29445-64-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-allyl-2,3-dimethoxyphenol
• 英文别名: 4-allyl-dimethoxyphenol；dimethoxy-4-allylphenol；allyl dimethoxyphenol；6-Methoxy eugenol；2,3-dimethoxy-4-prop-2-enylphenol
• CAS: 29445-64-5
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: PVUBHWCTFDCTSX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-allyl-2,3-dimethoxyphenol 、 碘乙烷 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 3-(4-Ethoxy-2,3-dimethoxyphenyl)propen
  参考文献：
  名称：

  Mucronustyrene, mucronulastyrene and villostyrene, cinnamylphenols from Machaerium mucronulatum and M. villosum

  摘要：

  DOI：

  10.1016/s0031-9422(00)94595-3
• 作为产物：
  描述：

  5,6,6-trimethoxycyclohexa-2,4-dienone 在 二氯乙基铝 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 72.0h， 生成 4-allyl-2,3-dimethoxyphenol
  参考文献：
  名称：

  Complete π-Facial Diastereoselectivity in Diels−Alder Reactions of Dissymmetric 2,4-Cyclohexadienones

  摘要：

  [GRAPHIC]The studies in the Diels-Alder reactions of 5-methoxy-masked o-benzoquinone (1a, R = OMe) and simple dissymmetric 2,4-cyclohexadienones 1b-e with methyl vinyl ketone, styrene, and benzyl vinyl ether are described. The dienones 1b-e reacted with dienophiles to form syn adducts (dienophile approach is syn to allylic methoxy group) exclusively.

  DOI：

  10.1021/ol020087o

文献信息

• Selective Claisen rearrangement and iodination for the synthesis of polyoxygenated allyl phenol derivatives
  作者：Antonella Bochicchio、Rossella Cefola、Sabine Choppin、Françoise Colobert、Maria Antonietta Di Noia、Maria Funicello、Gilles Hanquet、Isabella Pisano、Simona Todisco、Lucia Chiummiento

  DOI：10.1016/j.tetlet.2016.07.079

  日期：2016.9

  Allyl aryl ethers and allyl phenol derivatives were prepared starting from commercial or synthetized phenols. Either Williamson reaction or Et2AlCl catalyzed Claisen rearrangement was performed to obtain the polyoxygenated molecules. The pivotal allyl phenols were then modified by methylation, iodocyclization or electrophilic aromatic iodination to afford the polyoxygenated derivatives in good to excellent

  从商业或合成的苯酚开始制备烯丙基芳基醚和烯丙基苯酚衍生物。进行威廉姆森反应或Et 2 AlCl催化的克莱森重排以获得多加氧分子。然后通过甲基化，碘环化或亲电子碘化碘化对枢轴烯丙基苯酚进行改性，从而以良好或优异的收率得到多氧化衍生物。此外，还研究了它们对革兰氏阳性和革兰氏阴性细菌的抗菌性能。
• Cooling Agent and TRPM8 Activator
  申请人：Kao Corporation

  公开号：US20140329910A1

  公开（公告）日：2014-11-06

  Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein R 1 represents a hydrogen atom; R 2 represents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; R 3 represents a hydrogen atom or a hydroxyl group; R 4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; R 5 represents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and R 6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

  提供了一种具有出色的TRPM8激活作用的冷却剂、一种TRPM8激活剂、一种赋予冷感的方法，以及一种用于赋予冷感的新化合物。公开了一种冷却剂，其包括以下式（1）所代表的化合物作为活性成分： 其中R1代表氢原子；R2代表氢原子、羟基或具有1至3个碳原子的烷氧基；R3代表氢原子或羟基；R4代表氢原子、具有1至6个碳原子的烷基、具有2至6个碳原子的烯基，或具有1至3个碳原子的烷氧基；R5代表氢原子或具有1至3个碳原子的烷氧基；R6代表氢原子、羟基、具有1至14个碳原子的烷氧基、总共具有2至12个碳原子的烷氧烷氧基、具有3至12个碳原子的环烷氧基、具有6至12个碳原子的芳基氧基、总共具有7至14个碳原子的芳基烷氧基，或总共具有2至12个碳原子的烷酰氧基。
• [EN] METHODS FOR LIGNIN DEPOLYMERIZATION USING THIOLS<br/>[FR] PROCÉDÉS DE DÉPOLYMÉRISATION DE LIGNINE À L'AIDE DE THIOLS
  申请人：UNIV MICHIGAN STATE

  公开号：WO2018195000A1

  公开（公告）日：2018-10-25

  The disclosure relates to a method for depolymerizing lignin. The method includes reacting a lignin compound with a thiol compound to depolymerize the lignin compound and to form a depolymerized lignin product having a reduced molecular weight relative to the lignin compound prior to reacting. The method can further include forming an oxidized thiol reaction product between two thiol groups from one or more thiol compounds, and then reducing the oxidized thiol reaction product to re-form or regenerate the thiol compound for further lignin depolymerization.

  该披露涉及一种降解木质素的方法。该方法包括将木质素化合物与硫醇化合物反应，以降解木质素化合物并形成一个相对于反应前的木质素化合物具有降低分子量的降解木质素产物。该方法还可以包括形成两个硫醇化合物中的一个或多个硫醇基之间的氧化硫醇反应产物，然后还原氧化硫醇反应产物以重新形成或再生用于进一步木质素降解的硫醇化合物。
• MOLECULARLY IMPRINTED POLYMERS FOR TREATING TOBACCO MATERIAL AND FILTERING SMOKE FROM SMOKING ARTICLES
  申请人：Byrd Crystal Dawn Hege

  公开号：US20120291793A1

  公开（公告）日：2012-11-22

  The invention provides a method of isolating certain target compounds from tobacco, tobacco materials or smoke generated by a smoking article. The method can be used to remove undesirable compounds from tobacco, tobacco materials, or tobacco smoke. The method can also be used to remove flavor compounds from tobacco or tobacco materials, which can then be used as flavor components for tobacco material used in smoking articles and smokeless tobacco compositions.

  本发明提供了一种从烟草、烟草材料或由吸烟物品产生的烟雾中分离出特定目标化合物的方法。该方法可用于从烟草、烟草材料或烟草烟雾中去除不良化合物。该方法还可用于从烟草或烟草材料中去除风味化合物，这些化合物可以作为吸烟物品和无烟烟草组合中使用的烟草材料的风味成分。
• COOLING AGENT AND TRPM8 ACTIVATOR
  申请人：Kao Corporation

  公开号：EP2787051A1

  公开（公告）日：2014-10-08

  Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein R1 represents a hydrogen atom; R2 represents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; R3 represents a hydrogen atom or a hydroxyl group; R4 represents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; R5 represents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.

  本文提供了一种具有出色的 TRPM8 激活作用的降温剂、一种 TRPM8 激活剂、一种赋予降温感觉的方法，以及一种可用于赋予降温感觉的新型化合物。本发明公开了一种降温剂，其活性成分包括下式（1）所代表的化合物： 其中 R1 代表氢原子；R2 代表氢原子、羟基或具有 1 至 3 个碳原子的烷氧基；R3 代表氢原子或羟基；R4 代表氢原子、具有 1 至 6 个碳原子的烷基、具有 2 至 6 个碳原子的烯基或具有 1 至 3 个碳原子的烷氧基；R5 代表氢原子或具有 1 至 3 个碳原子的烷氧基；R6 代表氢原子、羟基、具有 1 至 14 个碳原子的烷氧基、具有 2 至 12 个碳原子的烷氧基、具有 3 至 12 个碳原子的环烷氧基、具有 6 至 12 个碳原子的芳氧基、具有 7 至 14 个碳原子的烷氧基或具有 2 至 12 个碳原子的烷酰氧基。