1,3-Dihydrothieno<3,4-c>pyridin | 37537-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,3-Dihydrothieno<3,4-c>pyridin
• 英文别名: 1,3-dihydro-thieno[3,4-c]pyridine；1,3-Dihydrothieno[3,4-c]pyridine
• CAS: 37537-47-6
• 化学式: C₇H₇NS
• 分子量: 137.205
• InChiKey: CVELJMJLCCKKEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  38.2
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• Bicyclic pyrazolidinones
  申请人：ELI LILLY AND COMPANY

  公开号：EP0203722A1

  公开（公告）日：1986-12-03

  Bicyclic pyrazolidinones which have antimicrobial and/or herbicidal properties are discussed. The use of these compounds in pharmaceutical compositions, herbicidal compositions, and methods for treating bacterial infections and controlling undesired plants is set forth. The bicyclic pyrazolidinones have the formula wherein: either R1 or R2 is hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, perfluoro C2 to C4 alkyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl, substituted phenyl, nitro br cyano; a group of the formula wherein X is fluoro, chloro, bromo or iodo; a group of the formula wherein Z is 0, 1 or 2 and Rs is C1 to C6 alkyl, C1 to C6 substituted alkyl, phenyl, substituted phenyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl or a heterocyclic ring; a group of the formula wherein R6 is hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, perfluoro C2 to C4 alkyl, trihalomethyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl or substituted phenyl; a group of the formula wherein R7 is hydrogen, an organic or inorganic cation, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl, substituted phenyl, a carboxy protecting group, or a non-toxic, metabolically-labile ester-forming group; or a group of the formula wherein R8 is hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 substituted alkylaryl, phenyl, or substituted phenyl; a group of the formula wherein -N≡Q is a quaternary ammonium group; or a group of the formula -CH2-S-Heterocyclic-ring and the other of R1 or R2 is a group of the formula wherein R9 is hydrogen, an organic or inorganic cation, a carboxy protecting group, or a non-toxic, metabolically-labile ester-forming group; and R3 and R4 are the same or different and are hydrogen, C1 to C6 alkyl, C1 to C6 substituted alkyl, C7 to C12 alkylaryl, C7 to C12 substituted alkylaryl, phenyl, substituted phenyl or a group of the formula wherein R10 has the same definition as R7; with the exception that, when R1 and R2 are a group of the formula R3 and R4 are not methyl; or a pharmaceutically-acceptable salt thereof.

  本文讨论了具有抗菌和/或除草特性的双环吡唑烷酮。阐述了这些化合物在药物组合物、除草组合物中的用途，以及治疗细菌感染和控制有害植物的方法。双环吡唑烷酮的化学式为 其中 R1 或 R2 是氢、C1 至 C6 烷基、C1 至 C6 取代烷基、全氟 C2 至 C4 烷基、C7 至 C12 烷芳基、C7 至 C12 取代烷芳基、苯基、取代苯基、硝基溴氰基； 式中的基团 其中 X 为氟、氯、溴或碘； 式中的基团 其中 Z 是 0、1 或 2，Rs 是 C1 至 C6 烷基、C1 至 C6 取代的烷基、苯基、取代的苯基、C7 至 C12 烷芳基、C7 至 C12 取代的烷芳基或杂环； 式中的基团 其中 R6 是氢、C1 至 C6 烷基、C1 至 C6 取代的烷基、全氟 C2 至 C4 烷基、三卤甲基、C7 至 C12 烷芳基、C7 至 C12 取代的烷芳基、苯基或取代的苯基； 式中的基团 其中 R7 是氢、有机或无机阳离子、C1-C6 烷基、C1-C6 取代烷基、C7-C12 烷芳基、C7-C12 取代烷芳基、苯基、取代苯基、羧基保护基团或无毒、代谢上易形成酯的基团； 或一个式中的基团 其中 R8 是氢、C1 至 C6 烷基、C1 至 C6 取代的烷基、C7 至 C12 取代的烷芳基、苯基或取代的苯基； 式中的基团 其中 -N≡Q 是季铵基团； 或式中的基团 -CH2-S-杂环，而 R1 或 R2 中的另一个是式中的基团 其中 R9 是氢、有机或无机阳离子、羧基保护基团或无毒、可代谢的成酯基团；以及 R3 和 R4 相同或不同，并且是氢、C1 至 C6 烷基、C1 至 C6 取代的烷基、C7 至 C12 烷芳基、C7 至 C12 取代的烷芳基、苯基、取代的苯基或式中的基团 其中 R10 的定义与 R7 相同；但当 R1 和 R2 为式中的基团时 R3 和 R4 不是甲基；或其药学上可接受的盐。
• Penem derivatives
  申请人：FARMITALIA CARLO ERBA S.r.l.

  公开号：EP0236880A2

  公开（公告）日：1987-09-16

  There are provided compounds of formula I : wherein R' is hydrogen or a C1-C4 alkyl group either unsubstituted or substituted by one or more substituents chosen from a free or protected hydroxy or halogen atom; R2 is a free or esterified carboxy group or carboxylate anion; R3 and R4 are each independently hydrogen or organic group, X is ,-S-, Q is either (a") free or protected hydroxy, or (b") a C1-C4 acyloxy, or (c") carbamoyloxy OCONH2, or (d") an optionally substituted heterocyclylthio group, or (e") an optionally substituted imido group, or (f") an optionally substituted quaternary ammonium group or (g") a halogen atom, and the pharmaceutically or veterinarily acceptable salts thereof. There are provided also methods for preparing compounds of formula 1. The compounds of formula I are useful as antibacterial agents.

  提供了式 I 的化合物： 其中 R'是氢或未取代的 C1-C4 烷基或被一个或多个取代基取代的 C1-C4 烷基，取代基可选自游离的或受保护的羟基或卤原子； R2 是游离的或酯化的羧基或羧酸阴离子； R3和R4各自独立地为氢或有机基团、 X 是 ,-S-, Q是 (a") 自由或受保护的羟基，或 (b") C1-C4 乙酰氧基，或 (c") 氨基甲酰氧基 OCONH2，或 (d") 任选取代的杂环硫基，或 (e")任选取代的亚氨基，或 (f) 一个任选取代的季铵基团，或 (g")卤素原子，以及它们的药学或兽医学上可接受的盐类。 还提供了制备式 1 化合物的方法。式 I 化合物可用作抗菌剂。
• 1-carbacephalosporin antibiotics
  申请人：ELI LILLY AND COMPANY

  公开号：EP0327239A1

  公开（公告）日：1989-08-09

  7β-Acylamino-3-(quaternary ammonium)-1-carba(1-dethia)-3-cephem-4-carboxylic acids and derivatives are provided as antibiotics useful for treating infections in man and animals. Pharmaceutical formulations comprising the antibiotics and intermediates for their preparation are also provided.

  7β-Acylamino-3-(quaternary ammonium)-1-carba(1-dethia)-3-cephem-4-carboxylic acids 及其衍生物可作为治疗人类和动物感染的抗生素。还提供了包含这些抗生素的药物制剂及其制备中间体。
• Cyclohexanol derivatives, production and use thereof
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0415294A2

  公开（公告）日：1991-03-06

  The present invention relates to a compound of the formula: wherein A is halogen, N(O)mR¹R², N⊕R¹R²R³·X⊖, S(O)nR¹ or S⊕(O)mR¹R²·X⊖ where R¹,R² and R³ are each optionally substituted hydrocarbon or heterocyclic group, X⊖ is a counter anion; m is an integer of 0 or 1; n is an integer of 0 to 2; R¹ and R² may form a nitrogen-­containing or a sulfur-containing heterocyclic ring, which may further form a condensed ring, with the adjacent nitrogen atom or sulfur atom, and these nitrogen-containing or sulfur-containing heterocyclic rings may have substituents, B is O or NR⁴ where R⁴ is hydrogen or an optionally substituted lower alkyl or aryl group, D is 2-methyl-1-propenyl group or isobutyl group, and E is hydrogen, an optionally substituted hydrocarbon or an optionally substituted acyl group; provided that, when A is chlorine, E is an optionally substituted hydrocarbon or acyl excepting dinitrobenzoyl, a salt thereof, production and use thereof. The novel cyclohexanol derivatives of the present invention have angiogenesis inhibiting activity and anti-tumor activity, and they are used as anti-­rheumatic agents, therapeutic agents of psoriasis, therapeutic agents of diabetic retinopathy and anti-­tumor agents.

  本发明涉及一种式化合物： 其中A为卤素、N(O)mR¹R²、N⊕R¹R²R³-X⊖、S(O)nR¹或S⊕(O)mR¹R²-X⊖ 其中R¹、R²和R³各自为任选取代的烃基或杂环基，X⊖为反离子；m为0或1的整数；n为0至2的整数；R¹ 和 R² 可与相邻的氮原子或硫原子形成含氮或含硫杂环，并可进一步形成缩合环，这些含氮或含硫杂环可带有取代基、B 是 O 或 NR⁴，其中 R⁴ 是氢或任选取代的低级烷基或芳基；D 是 2-甲基-1-丙烯基或异丁基；E 是氢、任选取代的烃或任选取代的酰基；条件是，当 A 是氯时，E 是任选取代的烃基或酰基，但二硝基苯甲酰基、其盐、其生产和使用除外。 本发明的新型环己醇衍生物具有血管生成抑制活性和抗肿瘤活性，可用作抗风湿剂、银屑病治疗剂、糖尿病视网膜病变治疗剂和抗肿瘤剂。
• Solid electrolytic capacitor and method for producing the same
  申请人：Showa Denko K.K.

  公开号：EP1988556A2

  公开（公告）日：2008-11-05

  A solid electrolytic capacitor includes a valve acting metal having microfine pores, a dielectric film formed on a surface of the valve acting metal, and a solid electrolyte layer provided on the dielectric film, in which at least a portion of the solid electrolyte layer is of a lamellar structure. In particular, a solid electrolytic capacitor includes an electrically conducting polymer having a specified condensed ring structure containing (1) a solid electrolyte layer containing a sulfoquinone anion having a sulfo anion group and a quinone structure and other anion, and (2) a solid electrolyte layer containing an anthracenesulfonate ion and other anion.

  固体电解电容器包括具有微细孔隙的阀门作用金属、形成于阀门作用金属表面的介电膜以及设置在介电膜上的固体电解质层，其中固体电解质层的至少一部分为片状结构。具体而言，固体电解电容器包括具有特定缩合环结构的导电聚合物，其中包含（1）含有磺醌阴离子的固体电解质层，该阴离子具有磺阴离子基团和醌结构以及其他阴离子；以及（2）含有蒽磺酸离子和其他阴离子的固体电解质层。