1-(3,5-Bis-trifluoromethyl-phenyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-urea | 35685-17-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3,5-Bis-trifluoromethyl-phenyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-urea
• CAS: 35685-17-7
• 化学式: C₁₆H₈F₁₀N₂O
• 分子量: 434.236
• InChiKey: ZENPYCZPACZTTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.53
• 重原子数：
  29.0
• 可旋转键数：
  2.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  41.13
• 氢给体数：
  2.0
• 氢受体数：
  1.0

反应信息

• 作为产物：
  描述：

  三光气 、 间二(三氟甲基)苯胺 、 4-氟-3-三氟甲基苯胺 在 三乙胺 作用下， 以 乙腈 为溶剂， 以54.6 %的产率得到1-(3,5-Bis-trifluoromethyl-phenyl)-3-(4-fluoro-3-trifluoromethyl-phenyl)-urea
  参考文献：
  名称：

  Discovery of N,N'‐diarylurea molecules with activity against multidrug‐resistant Staphylococcus aureus

  摘要：

  The emergence and global spread of methicillin‐resistant Staphylococcus aureus (MRSA) pose a serious threat to public health, underscoring the urgent need for novel antibacterial interventions. Here, we screened 18 newly synthesized N,N’‐diarylurea derivatives to identify compounds with activity against MRSA. Our investigations led to the discovery of a small molecule, SCB‐24, which exhibited promising antimicrobial activity against MRSA USA300. Notably, SCB‐24 demonstrated high activity even in the presence of 10% fetal bovine serum and showed excellent selectivity for bacterial over mammalian cells. SCB‐24 also showed potent activity against various MRSA strains, including those resistant to second‐ and third‐line antibiotics. Importantly, the efficacy of SCB‐24 was inferior to that of vancomycin in MRSA‐infected Galleria mellonella larvae. Overall, our findings suggest that SCB‐24 has great potential as a new therapeutic for multidrug‐resistant S. aureus infections.

  DOI：

  10.1002/ardp.202400047