N-[6-(ethene-1-oxy)-5-hydroxy-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-4-tert-butyl benzene sulphonamide | 1257099-42-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[6-(ethene-1-oxy)-5-hydroxy-2-(pyrimidin-2-yl)-pyrimidin-4-yl]-4-tert-butyl benzene sulphonamide
• 英文别名: 4-(1,1-dimethylethyl)-N-[6-(ethenyloxy)-5-hydroxy[2,2'-bipyrimidin]-4-yl]-Benzenesulfonamide；4-tert-butyl-N-(6-ethenoxy-5-hydroxy-2-pyrimidin-2-ylpyrimidin-4-yl)benzenesulfonamide
• CAS: 1257099-42-5
• 化学式: C₂₀H₂₁N₅O₄S
• 分子量: 427.484
• InChiKey: NVFOHQFYZFTQJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  136
• 氢给体数：
  2
• 氢受体数：
  9

文献信息

• HPLC METHOD FOR THE ANALYSIS OF BOSENTAN AND RELATED SUBSTANCES AND USE OF THESE SUBSTANCES AS REFERENCE STANDARDS AND MARKERS
  申请人：Generics [UK] Limited

  公开号：EP2350028A1

  公开（公告）日：2011-08-03
• HPLC METHOD FOR THE ANALYSIS OF BOSETAN AND RELATED SUBSTANCES AND USE OF THESE SUBSTANCES AS REFERENCE STANDARDS AND MARKERS
  申请人：Vijaya Kumar Erra Koteswara Satya

  公开号：US20110263853A1

  公开（公告）日：2011-10-27

  The present invention relates to a new HPLC method for the analysis of the drug substance bosentan and related substances and to the use of said substances as reference standards and markers.
• US8975402B2
  申请人：——

  公开号：US8975402B2

  公开（公告）日：2015-03-10
• [EN] HPLC METHOD FOR THE ANALYSIS OF BOSENTAN AND RELATED SUBSTANCES AND USE OF THESE SUBSTANCES AS REFERENCE STANDARDS AND MARKERS<br/>[FR] PROCÉDÉ CLHP POUR L'ANALYSE DE BOSENTAN ET DE SUBSTANCES APPARENTÉES ET UTILISATION DE CES SUBSTANCES EN TANT QUE STANDARDS DE RÉFÉRENCE ET MARQUEURS
  申请人：GENERICS UK LTD

  公开号：WO2010061210A1

  公开（公告）日：2010-06-03

  The present invention relates to a new HPLC method for the analysis of the drug substance bosentan and related substances and to the use of said substances as reference standards and markers.