diphenyl (1-(tert-butylamino)-2-phenylethylidene)phosphoramidate | 1207731-54-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl (1-(tert-butylamino)-2-phenylethylidene)phosphoramidate
• CAS: 1207731-54-1
• 化学式: C₂₄H₂₇N₂O₃P
• 分子量: 422.464
• InChiKey: IWJKDJAKQKNXOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.28
• 重原子数：
  30.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  59.92
• 氢给体数：
  1.0
• 氢受体数：
  3.0

文献信息

• Synthesis and SAR of sulfonyl- and phosphoryl amidine compounds as anti-resorptive agents
  作者：Myung Yun Lee、Myung Hee Kim、Jinho Kim、Seok Hwan Kim、Bum Tae Kim、In Howa Jeong、Sukbok Chang、Seong Hwan Kim、Sung-Youn Chang

  DOI：10.1016/j.bmcl.2009.11.104

  日期：2010.1

  Sulfonyl amidines (1) and phosphoryl amidines (2), which were efficiently synthesized via a Cu-catalyzed one pot reaction, showed potent anti-bone resorptive activity in vitro. Structure activity relationship studies led to the identification of numerous osteoclast differentiation inhibitors. (C) 2009 Elsevier Ltd. All rights reserved.