1H-吲哚-2-甲胺盐酸盐 | 1159692-99-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 1H-吲哚-2-甲胺盐酸盐
• 英文名称: (1H-indol-2-yl)methanamine hydrochloride
• 英文别名: 1H-indol-2-ylmethanamine;hydrochloride
• CAS: 1159692-99-5
• 化学式: C₉H₁₀N₂*ClH
• 分子量: 182.653
• InChiKey: OOENXMOJCVOPPC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.05
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  41.8
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1H-吲哚-2-甲胺盐酸盐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 生成 tert-butyl ((1H-indol-2-yl)methyl)carbamate
  参考文献：
  名称：

  Indoles, Indazoles, and Related Analogs for Inhibiting YAP/TAZ-TEAD

  摘要：

  The present disclosure relates to novel compounds, to said compounds for use as a medicine, more in particular for the prevention or treatment of diseases mediated by activity of YAP/TAZ-TEAD transcription, yet more in particular for the prevention or treatment of cancer or fibrosis. The present disclosure also relates to a method for the prevention or treatment of said diseases comprising the use of the novel compounds.

  公开号：

  US20230202985A1
• 作为产物：
  描述：

  methyl 5-(2-aminobenzyl)oxazole-4-carboxylate 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以63%的产率得到1H-吲哚-2-甲胺盐酸盐
  参考文献：
  名称：

  Novel synthesis of benzofuran- and indol-2-yl-methanamine derivatives

  摘要：

  We report on a novel synthesis towards benzofuran-2-yl-methanamine and indol-2-yl-methanamine derivatives by using ortho-methoxy and ortho-nitro substituted phenylacetic acids as starting material, respectively. For each compound series, a key intermediate bearing the oxazole-4-carboxylic acid methylester moiety was produced. Refluxing the ortho-methoxy series in HBr/HAc produced the desired benzofuran-2-yl-methanamines. Accordingly, for the synthesis of indoles the nitro-group was first reduced and reaming these intermediates in HCl gave the corresponding indol-2-yl-methanamines. The method worked well with electron donating substituents. Limitations regarding electron withdrawing substituents are discussed. This straightforward synthetic procedure can be a useful approach to generate a variety of substituted benzofuran-2-yl-methanamine and indol-2-yl-methanamine compounds by starting from readily available phenylacetic acid derivatives. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.11.015

文献信息

• [EN] CHEMICAL COMPOUNDS AS ANTIBIOTICS<br/>[FR] COMPOSÉS CHIMIQUES UTILISÉS COMME ANTIBIOTIQUES
  申请人：ANTABIO SAS

  公开号：WO2018172423A1

  公开（公告）日：2018-09-27

  The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p¸ q, L, ׇ, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

  该发明涉及一种化合物，根据式（I）为茚烷衍生物，或其药学上可接受的盐，[式（I）]其中R1、R2、R3、n、R4、p、q、L、ׇ、X和m如本文所定义。这些化合物在抗菌感染的治疗中非常有用，可以作为独立抗生素使用，也可以与其他抗生素联合使用。这些化合物还可以在体外使用，例如在清洁组合物中。
• [EN] SERINE/THREONINE KINASE INHIBITORS<br/>[FR] INHIBITEURS DE SÉRINE/THRÉONINE KINASE
  申请人：ARRAY BIOPHARMA INC

  公开号：WO2012118850A1

  公开（公告）日：2012-09-07

  Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

  具有公式I的化合物，其中Z，Z1，Z2，Z3，R3a，R3b和Rb如本文所定义，是ERK激酶抑制剂。还公开了用于治疗过度增殖性疾病的组合物和方法。
• SERINE/THREONINE KINASE INHIBITORS
  申请人：Blake James F.

  公开号：US20130338140A1

  公开（公告）日：2013-12-19

  Compounds having the formula I wherein Z, Z 1 Z 2 Z, R 3a , R 3b and R b and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

  具有I式的化合物，在此式中Z，Z1Z2Z，R3a，R3b和R3c的定义为ERK激酶的抑制剂。还披露了治疗过度增殖性疾病的组合物和方法。
• Serine/threonine kinase inhibitors
  申请人：Blake James F.

  公开号：US09133187B2

  公开（公告）日：2015-09-15

  Compounds having the formula I wherein Z, Z1 Z2 Z3, R3a, R3b and Rb and as defined herein are inhibitors of ERK kinase. Also disclosed are compositions and methods for treating hyperproliferative disorders.

  具有I式的化合物，其中Z，Z1，Z2，Z3，R3a，R3b和Rb如本文所定义，是ERK激酶的抑制剂。还揭示了用于治疗过度增殖性疾病的组合物和方法。
• Chemical compounds as antibiotics
  申请人：Antabio SAS

  公开号：US11000511B2

  公开（公告）日：2021-05-11

  The invention relates to a compound which is an indane derivative according to Formula (I), or a pharmaceutically acceptable salt thereof, [FORMULA (I)] wherein R1, R2, R3, n, R4, p, q, L, X and m are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics. The compounds can also be used in vitro, for example in cleaning compositions.

  本发明涉及一种化合物，它是符合式 (I) 的茚满衍生物，或其药学上可接受的盐，[式 (I)] 其中 R1、R2、R3、n、R4、p、q、L、X 和 m 如本文所定义。这些化合物可作为单独的抗生素或与其他抗生素联合使用，用于治疗抗菌感染。这些化合物还可用于体外治疗，例如清洁组合物。