2-(3,4-Diamino-2-fluorophenyl)propan-2-ol | 1356907-07-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3,4-Diamino-2-fluorophenyl)propan-2-ol
• CAS: 1356907-07-7
• 化学式: C₉H₁₃FN₂O
• 分子量: 184.213
• InChiKey: LGRSMMMEBMJSBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  72.3
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3,4-Diamino-2-fluorophenyl)propan-2-ol 、 2-氯-6-三氟甲基烟酸 在 硼烷四氢呋喃络合物 作用下， 以 乙二醇单丁醚 为溶剂， 生成 、
  参考文献：
  名称：

  Discovery of Benzodiazepine Sulfonamide-Based Bombesin Receptor Subtype 3 Agonists and Their Unusual Chirality

  摘要：

  We report herein the discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 (BRS-3) agonists and their unusual chirality. Starting from a high-throughput screening lead, we prepared a series of BRS-3 agonists with improved potency and pharmacokinetic properties, of which compound 8a caused mechanism-based, dose-dependent food intake reduction and body weight loss after oral dosing in diet-induced obese mice. This effort also led to the discovery of a novel family of chiral molecules originated from the conformationally constrained seven-membered diazepine ring.

  DOI：

  10.1021/ml200207w

文献信息

• LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT HAVING THE SAME
  申请人：CHI MEI CORPORATION

  公开号：US20170029703A1

  公开（公告）日：2017-02-02

  The present invention relates to a liquid crystal alignment agent, a liquid crystal alignment film and a liquid crystal display element. The liquid crystal alignment agent includes a polymer composition (A) synthesized by tetracarboxylic dianhydride compound (a) and diamine compound (b), and a solvent (B). The diamine compound (b) includes diamine (b-1) shown as following formula (I) and diamine (b-2): in formula (I), R 1 represents a linear or branched alkyl of 1 to 6 carbons, a linear or branched hydroxyl alkyl of 1 to 6 carbons, an alkoxy of 1 to 6 carbons, an alkylthio of 1 to 6 carbons, a halogen atom, an amino group or a nitro group; R 2 represents a methylene group, a divalent alkyl of 2 to 10 carbons, a divalent alkenyl of 2 to 7 carbons or a divalent alkynyl of 2 to 6 carbons; and a represents an integer of 0 to 3.
• US9976088B2
  申请人：——

  公开号：US9976088B2

  公开（公告）日：2018-05-22