3(S)-Methyl-4-Benzyl Succinate | 1236420-05-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3(S)-Methyl-4-Benzyl Succinate
• 英文别名: (3S)-3-methyl-4-oxo-4-phenylmethoxybutanoic acid
• CAS: 1236420-05-5
• 化学式: C₁₂H₁₄O₄
• 分子量: 222.241
• InChiKey: RARNEZUOCRRMPW-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Retroviral protease inhibitors
  申请人：Monsanto Company

  公开号：US20030195227A1

  公开（公告）日：2003-10-16

  N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

  含有羟乙基胺基团的N-杂环化合物可作为逆转录病毒蛋白酶抑制剂，特别是作为HIV蛋白酶的抑制剂。
• Retrovial protease inhibitors
  申请人：MONSANTO COMPANY

  公开号：EP0957093A2

  公开（公告）日：1999-11-17

  N-heterocyclic moiety containing hydroxyethylamine compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease, having the formula wherein A is selected from

  含羟乙基胺的 N-杂环分子化合物是有效的逆转录病毒蛋白酶抑制剂，特别是 HIV 蛋白酶抑制剂，其式为 其中 A 选自
• RETROVIRAL PROTEASE INHIBITORS
  申请人：MONSANTO COMPANY

  公开号：EP0641325A1

  公开（公告）日：1995-03-08
• NOVEL ANTIVIRAL AND ANTITUMORAL COMPOUNDS
  申请人：KATHOLIEKE UNIVERSITEIT LEUVEN, KU LEUVEN R&D

  公开号：US20170022242A1

  公开（公告）日：2017-01-26

  The present invention relates to novel phosphate-modified nucleosides, such as phosphoramidate nucleosides. The invention also relates to the use of these novel phosphate-modified nucleosides to treat or prevent viral infections and proliferative diseases (such as cancer) and their use to manufacture a medicine to treat or prevent viral infections and proliferative diseases particularly infections with viruses belonging to the HCV family.
• US5648364A
  申请人：——

  公开号：US5648364A

  公开（公告）日：1997-07-15