4-(1,8-naphthyridin-2-yl)butan-1-ol | 1197192-13-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(1,8-naphthyridin-2-yl)butan-1-ol
• CAS: 1197192-13-4
• 化学式: C₁₂H₁₄N₂O
• 分子量: 202.256
• InChiKey: XECCGBLATYZKJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  46
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(1,8-naphthyridin-2-yl)butan-1-ol 在 20% palladium hydroxide-activated charcoal 、 氢气 、 双(三甲基硅烷基)氨基钾 、 戴斯-马丁氧化剂 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 为溶剂， 反应 23.0h， 生成 (S,Z)-methyl 9-(8-acetyl-5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)-3-(3-(trifluoromethyl)phenyl)non-5-enoate
  参考文献：
  名称：

  METHOD OF MAKING TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID COMPOUNDS

  摘要：

  本申请涉及制备化合物I的方法：或其药用可接受的盐或溶剂。

  公开号：

  US20180282327A1
• 作为产物：
  描述：

  4-(1,8-萘啶-2-基)丁酸乙酯 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 以55%的产率得到4-(1,8-naphthyridin-2-yl)butan-1-ol
  参考文献：
  名称：

  α_vβ₃ Integrin-Targeting Arg-Gly-Asp (RGD) Peptidomimetics Containing Oligoethylene Glycol (OEG) Spacers

  摘要：

  RGD peptides are used in biomaterials science for surface modifications with a view to elicit selective cellular responses. Our objective is to replace peptides by small peptidomimetics acting similarly. We designed novel molecules targeting alpha(v)beta(3) integrin and featuring spacer-arms (for surface grafting), which do not disturb the biological activity, from (L) N-(3-(trifluoromethyl)benzenesulfonyl) tyrosine used as scaffold. Various Arg-mimics were fixed on the phenol function, and the ortho position was used for the Coupling of OEG spacers. All peptidomimetics were active in the nM range in a binding test toward human alpha(v)beta(3) integrin (IC50 = 0.1 to 1.7 nM) and selective versus platelet integrin alpha(IIb)beta(3) Selected compounds revealed excellent ability to inhibit bone cells adhesion on vitronectin. Modeling and docking studies were performed for comparing the most active RGD peptidomimetic to cilengitide, i.e., cyclo-[RGDfN(Me)V]-. Lastly, the adhesion of endothelial cells on a cultivation support grafted with RGD peptidomimetics was significantly improved.

  DOI：

  10.1021/jm901133z

文献信息

• Method of making tetrahydronaphthyridinyl nonanoic acid compounds
  申请人：SciFluor Life Sciences, Inc.

  公开号：US10253025B2

  公开（公告）日：2019-04-09

  The present application relates to methods of preparing a compound of formula I: or a pharmaceutically acceptable salt or solvate thereof.

  本申请涉及制备式 I 化合物的方法： 或其药学上可接受的盐或溶液的方法。
• [EN] METHOD OF MAKING TETRAHYDRONAPHTHYRIDINYL NONANOIC ACID COMPOUNDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE COMPOSÉS D'ACIDE TÉTRAHYDRONAPHTHYRIDINYLE NONANOÏQUE
  申请人：SCIFLUOR LIFE SCIENCES INC

  公开号：WO2018183795A1

  公开（公告）日：2018-10-04

  The present application relates to methods of preparing a compound of formula I: (I), or a pharmaceutically acceptable salt or solvate thereof.