3-[N-(4-chlorobenzyl)-3-(α,α-dimethylbenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid | 136694-07-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-[N-(4-chlorobenzyl)-3-(α,α-dimethylbenzyl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid
• 英文别名: 3-[1-[(4-Chlorophenyl)methyl]-3-(2-phenylpropan-2-yl)-5-(quinolin-2-ylmethoxy)indol-2-yl]-2,2-dimethylpropanoic acid
• CAS: 136694-07-0
• 化学式: C₃₉H₃₇ClN₂O₃
• 分子量: 617.187
• InChiKey: ZQMMGXOIRUYREW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.5
• 重原子数：
  45
• 可旋转键数：
  10
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• (Quinolin-2-ylmethoxy) indoles as inhibitors of the biosynthesis of leukotrienes
  申请人：MERCK FROSST CANADA INC.

  公开号：EP0419049B1

  公开（公告）日：1995-04-12
• Susceptibility Gene for Myocardial Infarction, Stroke, Paod and Methods of Treatment
  申请人：Helgadottir Anna

  公开号：US20080293750A1

  公开（公告）日：2008-11-27

  Linkage of myocardial infarction (MI) and a locus on chromosome 13q12 is disclosed. In particular, the FLAP gene within this locus is shown by genetic association analysis to be a susceptibility gene for MI and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a stating and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
• Susceptibility Gene for Myocardial Infarction, Stroke, and PAOD; Methods of Treatment
  申请人：Helgadottir Anna

  公开号：US20100216863A1

  公开（公告）日：2010-08-26

  Polymorphisms in the FLAP and LTA4H gene are shown by genetic association analysis to be susceptibility markers for myocardial infarction (MI) and ACS, as well as stroke and PAOD. Pathway targeting for treatment and diagnostic applications in identifying those who are at risk of developing MI, ACS, stroke or PAOD, in particular are described. The invention also provides methods of prophylaxis therapy for MI in human subjects having a race including black African ancestry by administering to the subject a composition comprising a therapeutically effective amount of MI therapeutic agent that inhibits leukotriene synthesis in vivo. The invention also provides for compositions comprising a leukotriene synthesis inhibitor and a statin and methods of using these compositions to reduce C-reactive protein in a human subject at risk of MI, ACS, stroke and/or PAOD.
• US5204344A
  申请人：——

  公开号：US5204344A

  公开（公告）日：1993-04-20
• [EN] (QUINOLIN-2-YLMETHOXY)INDOLES AS INHIBITORS OF THE BIOSYNTHESIS OF LEUKOTRIENES<br/>[FR] (QUINOLEINE-2-YLMETHOXY)INDOLES UTILISES COMME INHIBITEURS DE LA BIOSYNTHESE DES LEUCOTRIENES
  申请人：——

  公开号：WO1994013293A2

  公开（公告）日：1994-06-23

  [EN] Compounds having formula (I) are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
  [FR] Des composés ayant la formule (I) sont des inhibiteurs de la biosynthèse des leucotriènes. Ces composés sont utiles comme agents anti-asthmatiques, anti-allergiques, anti-inflammatoires, et cytoprotecteurs. Ils sont également utiles pour traiter la diarrhée, l'hypertension, l'angine de poitrine, l'agrégation plaquettaire, les spasmes cérébraux, l'accouchement prématuré, les fausses couches, la dysménorrhée, et la migraine.