6-[(4-benzylcarbamoyl-benzyl)-(6-chloro-pyridine-3-sulfonyl)-amino]-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester | 900532-26-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-[(4-benzylcarbamoyl-benzyl)-(6-chloro-pyridine-3-sulfonyl)-amino]-5-oxo-[1,4]diazepane-1-carboxylic acid benzyl ester
• 英文别名: Benzyl 6-[[4-(benzylcarbamoyl)phenyl]methyl-(6-chloropyridin-3-yl)sulfonylamino]-5-oxo-1,4-diazepane-1-carboxylate
• CAS: 900532-26-5
• 化学式: C₃₃H₃₂ClN₅O₆S
• 分子量: 662.166
• InChiKey: NDPMPPPKTKNFJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  46
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  146
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• N-SUBSTITUTED HETEROCYCLIC SULFONAMIDES
  申请人：Elan Pharmaceuticals Inc.

  公开号：EP1838701A1

  公开（公告）日：2007-10-03
• N-substituted heterocyclic sulfonamides
  申请人：Neitzel Martin

  公开号：US20060270657A1

  公开（公告）日：2006-11-30

  The invention provides N-substituted heterocyclic-sulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R 1 , R 2 , Z and n are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
• US7569562B2
  申请人：——

  公开号：US7569562B2

  公开（公告）日：2009-08-04
• [EN] N-SUBSTITUTED HETEROCYCLIC SULFONAMIDES<br/>[FR] SULFAMIDES HETEROCYCLIQUES N-SUBSTITUES
  申请人：ELAN PHARM INC

  公开号：WO2006078753A1

  公开（公告）日：2006-07-27

  [EN] The invention provides N-substituted heterocyclic-sulfonamides for use in treating or preventing cognitive disorders, such as Alzheimer's Disease. Compounds of particular interest are defined by Formula (I), wherein R₁, R₂, Z and n are as described in the specification. The invention also encompasses pharmaceutical compositions comprising compounds of Formula (I) as well as methods of treating cognitive disorders using compounds of Formula (I).
  [FR] L'invention concerne des sulfamides hétérocycliques N-substitués à utiliser dans le traitement ou la prévention de troubles cognitifs, de type maladie d'Alzheimer. L'invention concerne des composés d'intérêt particulier définis par la formule (I), dans laquelle R₁, R₂, Z et n ont la signification indiquée dans la description. L'invention concerne également des compositions pharmaceutiques comprenant les composés de formule (I) ainsi que des procédés de traitement de troubles cognitifs faisant intervenir des composés de formule (I).