2-吡啶基铜 | 85311-89-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-吡啶基铜
• 英文名称: 2-pyridylcopper
• 英文别名: [(Cu(2-py))3].infin.
• CAS: 85311-89-3
• 化学式: C₅H₄N*Cu
• 分子量: 141.639
• InChiKey: ISJCSZJTXUFTFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.25
• 重原子数：
  7.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  12.89
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  2-吡啶基铜 生成 2,2'-联吡啶
  参考文献：
  名称：

  MALMBERG H.; NILSSON M., TETRAHEDRON, 42,(1986) N 14, 3981-3986

  摘要：

  DOI：
• 作为产物：
  描述：

  [CH3Al(2-pyridyl)3Li(tetrahydrofuran)] 、 copper(l) chloride 以 甲苯 为溶剂， 以64%的产率得到2-吡啶基铜
  参考文献：
  名称：

  Synthesis of the [MeAl(2-py)₃]^- Anion and Its Application as a Stable and Mild Pyridyl-Transfer Reagent (2-py = 2-Pyridyl)

  摘要：

  The thermally stable tris(pyridyl) Al(III) complex [MeAl(2-PY)(3)Li.THF] (1.THF), obtained from the reaction of lithiopyridine [2-pyLi] with MeAlCl2 (3:1 molar equiv, respectively), functions as a pyridyl-transfer reagent, as exemplified by the reaction of 1.THF with CuCl (1:1 molar equiv), which gives the Cu(I) organometallic [{Cu(2-py)}(3)](infinity) (2). The solid-state structures of 1, the dimer [MeAl(2-py)(3)Li](2) ([1](2)), and 2 are reported. Complex 2, which cannot be obtained by direct reaction of [2-pyLi] with CuCl, has a polymeric structure in which macrocyclic [Cu(2-py)](3) ring units form infinite offset stacks associated by short Cu...Cu interactions between three- and four-coordinate Cu(I) centers (2.762(3) Angstrom).

  DOI：

  10.1021/om049749z

文献信息

• [EN] 1-HYDROXYIMINO-3-PHENYL-PROPANES<br/>[FR] 1-HYDROXYIMINO-3-PHÉNYL-PROPANES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2012007365A1

  公开（公告）日：2012-01-19

  This invention relates to novel 1-hydroxyimino-3-phenyl-propanes of the formula (I) wherein R1 to R10 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and may be used as medicaments for the treatment of diseases such as type II diabetes.

  这项发明涉及式(I)中的新型1-羟基亚胺基-3-苯基丙烷，其中R1至R10如描述和权利要求书中所定义，并且其药学上可接受的盐。这些化合物是GPBAR1激动剂，可用作治疗疾病如2型糖尿病的药物。
• 2-Arylpyridines from 2-pyridylcopper/triphenylphosphine and iodoarenes
  作者：Hans Malmberg、Martin Nilsson

  DOI：10.1016/s0040-4020(01)87553-0

  日期：1986.1

  2-Arylpyridines are formed rather selectively in 50 to 80 % yields from 2-pyridylcopper and unactivated iodoarenes in the presence of one to two mol triphenylphosphine in toluene around 100 °C. The selectivity may be due to the ability of the copper(I) iodide-triphenylphosphine complex as a leaving group or may be discussed in terms of oxidative addition/reductive elimination. The unsymmetric coupling

  在1至2摩尔三苯基膦在甲苯中约100°C的条件下，由2-吡啶基铜和未活化的碘代芳烃以50至80％的收率选择性地形成2-芳基吡啶。选择性可能是由于碘化亚铜（I）-三苯基膦配合物作为离去基团的能力，或者可能是通过氧化加成/还原消除来讨论的。由于苯基铜/三苯基膦与2-碘吡啶的偶合也产生了2-苯基吡啶，因此不对称偶合反应可能是普遍的。
• [EN] PROCESS FOR PREPARATION OF 17-SUBSTITUTED STEROIDS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE STÉROÏDES 17-SUBSTITUÉS
  申请人：ALPHORA RES INC

  公开号：WO2013159225A1

  公开（公告）日：2013-10-31

  The specification relates to a process for preparation of 17-substituted steroid and intermediates useful therein. Embodiments of 17-substituted steroid have been shown as useful for treatment of androgen-dependent disorders, especially prostatic cancer, and also oestrogen-dependent5 disorders such as breast cancer.

  该规范与制备17-取代类固醇和有用中间体的过程有关。已经证明，17-取代类固醇的实施形式对于治疗雄激素依赖性疾病特别是前列腺癌，以及雌激素依赖性疾病如乳腺癌非常有用。
• Benzopiperidine derivatives
  申请人：Eisai Co., Ltd.

  公开号：US20040092737A1

  公开（公告）日：2004-05-13

  Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: 1 wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.

  式（I）所表示的苯并哌啶衍生物及其盐或水合物，制备该化合物的方法和包含该化合物的药物：1其中，变量如规范所述。这些化合物在预防和治疗各种炎症性疾病和免疫性疾病方面具有药效，例如类风湿性关节炎、特应性皮炎、银屑病、哮喘和器官移植伴随的排斥反应。
• Fungicidal composition and method for controlling plant diseases
  申请人：Nishide Hisaya

  公开号：US20060194849A1

  公开（公告）日：2006-08-31

  A fungicidal composition containing, as active ingredients, (a) a benzoylpyridine derivative represented by the following formula or its salt: wherein X is a halogen atom, a nitro group, a substitutable hydrocarbon group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group, a hydroxyl group, a substitutable alkylthio group, a cyano group, a carboxyl group which may be esterified or amidated, or a substitutable amino group, n is 1, 2, 3 or 4; R 1 is a substitutable alkyl group, R 2′ is a substitutable alkyl group, a substitutable alkoxy group, a substitutable aryloxy group, a substitutable cycloalkoxy group or a hydroxyl group, p is 1, 2 or 3, and R 2″ is a substitutable alkoxy group or a hydroxyl group, provided that at least two of R 2′ and R 2″ optionally form a condensed ring containing an oxygen atom and (b) at least one other fungicide.

  一种杀真菌组合物，包含以下活性成分：（a）一种苯甲酰吡啶衍生物或其盐，其化学式如下：其中X是卤素原子、硝基、可替代的碳氢基团、可替代的烷氧基团、可替代的芳氧基团、可替代的环烷氧基团、羟基、可替代的烷硫基团、氰基、可酯化或酰胺化的羧基或可替代的氨基团，n为1、2、3或4；R1是可替代的烷基团，R2'是可替代的烷基团、可替代的烷氧基团、可替代的芳氧基团、可替代的环烷氧基团或羟基，p为1、2或3，R2"是可替代的烷氧基团或羟基，但R2'和R2"中至少有两个可选地形成含氧原子的螺环；（b）至少一种其他杀真菌剂。