(2S,4S,5S,7S)-5-tert-butoxycarbonylamino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid | 853273-51-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (2S,4S,5S,7S)-5-tert-butoxycarbonylamino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid
• 英文别名: (2S,4S,5S,7S)-5-((tert-Butoxycarbonyl)amino)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanoic acid；(2S,4S,5S,7S)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-5-[(2-methylpropan-2-yl)oxycarbonylamino]-2-propan-2-ylnonanoic acid
• CAS: 853273-51-5
• 化学式: C₃₀H₅₁NO₈
• 分子量: 553.737
• InChiKey: WXHZDBFASZUCLQ-QORCZRPOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  39
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  124
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (2S,4S,5S,7S)-5-tert-butoxycarbonylamino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonanoic acid 、 叔丁基二甲基氯硅烷 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  [EN] ORGANIC COMPOUNDS
  [FR] COMPOSÉS ORGANIQUES

  摘要：

  揭示了具有抑制肾素作用的δ-氨基-Ϝ-羟基-ω-芳基-烷酸酰胺化合物的化学式(I)及其盐。还揭示了包含这些化合物的药物组合物以及用于治疗高血压、动脉粥样硬化、不稳定性冠状动脉综合征、充血性心力衰竭、心肌肥大、心脏纤维化、心肌病后梗死、不稳定性冠状动脉综合征、舒张功能障碍、慢性肾脏疾病、肝纤维化、糖尿病引起的并发症（如肾病、血管病和神经病变）、冠状动脉疾病、血管成形术后再狭窄、眼内压升高、青光眼、异常血管生长、高醛固酮症、认知障碍、阿尔茨海默病、痴呆、焦虑状态和认知障碍的治疗方法。

  公开号：

  WO2005051895A1

文献信息

• Organic Compounds
  申请人：Maibaum Juergen Klaus

  公开号：US20090076062A1

  公开（公告）日：2009-03-19

  Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

  揭示了具有抑制肾素作用的δ-氨基-γ-羟基-ω-芳基-烷酸酰胺化合物的化学式(I)及其盐。还揭示了包括这些化合物的药物组合物以及用于治疗高血压、动脉粥样硬化、不稳定性冠状动脉综合征、充血性心力衰竭、心肌肥大、心脏纤维化、心肌梗死后心肌病、不稳定性冠状动脉综合征、舒张功能障碍、慢性肾病、肝纤维化、糖尿病并发症（如肾病、血管病和神经病变）、冠状血管疾病、血管成形术后再狭窄、眼内压升高、青光眼、异常血管生长、高醛固酮症、认知障碍、阿尔茨海默病、痴呆症、焦虑状态和认知障碍的治疗方法。
• [EN] ALTERNATIVE SYNTHESIS OF RENIN INHIBITORS AND INTERMEDIATES THEREOF<br/>[FR] SYNTHESE ALTERNATIVE D'INHIBITEURS DE RENINES ET D'INTERMEDIAIRES DE CELLES-CI
  申请人：NOVARTIS AG

  公开号：WO2006024501A1

  公开（公告）日：2006-03-09

  The present invention relates to synthetic routes to prepare a compound of the formula (A); wherein R

  这项发明涉及合成路线，用于制备化合物（A）的公式；其中 R
• Alternative synthesis of renin inhibitors and intermediates thereof
  申请人：NOVARTIS AG

  公开号：EP1978012A1

  公开（公告）日：2008-10-08

  The present invention relates to synthetic routes to prepare a compound of the formula wherein R1 is halogen, C1-6halogenalkyl, C1-6alkoxy-C1-6alkyloxy or C1-6alkoxy-C1-6alkyl; R2 is halogen, C1-4alkyl or C1-4alkoxy; R3 and R4 are independently branched C3-6alkyl; and R5 is cycloalkyl, C1-6alkyl, C1-6hydroxyalkyl, C1-6alkoxy-C1-6alkyl, C1-6alkanoyloxy-C1-6alkyl, C1-6aminoalkyl, C1-6alkylamino-C1-6alkyl, C1-6dialkylamino-C1-6alkyl, C1-6alkanoylamino-C1-6alkyl, HO(O)C-C1-6alkyl, C1-6alkyl-O-(O)C-C1-6alkyl, H2N-C(O)-C1-6alkyl, C1-6alkyl-HN-C(O)-C1-6alkyl or (C1-6alkyl)2N-C(O)-C1-6alkyl; or a pharmaceutically acceptable salt thereof as well as key intermediates obtained when following these routes as well as their preparation.

  本发明涉及合成路线以制备一个化合物，其化学式为：其中，R1为卤素，C1-6卤代烷基，C1-6烷氧基-C1-6烷氧基或C1-6烷氧基-C1-6烷基；R2为卤素，C1-4烷基或C1-4烷氧基；R3和R4分别是支链C3-6烷基；R5为环烷基，C1-6烷基，C1-6羟基烷基，C1-6烷氧基-C1-6烷基，C1-6酰氧基-C1-6烷基，C1-6氨基烷基，C1-6烷基氨基-C1-6烷基，C1-6二烷基氨基-C1-6烷基，C1-6酰胺基烷基，HO(O)C-C1-6烷基，C1-6烷基-O-(O)C-C1-6烷基，H2N-C(O)-C1-6烷基，C1-6烷基-HN-C(O)-C1-6烷基或(C1-6烷基)2N-C(O)-C1-6烷基；或其药学上可接受的盐，以及在遵循这些路线时获得的关键中间体及其制备方法。
• Methods of treating alzheimer's disease using aryl alkanoic acid amides
  申请人：John Varghese

  公开号：US20060154926A1

  公开（公告）日：2006-07-13

  Disclosed are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (1) wherein the variables R 1 -R 8 and X are defined herein.

  本发明涉及使用式（1）中所述的化合物治疗阿尔茨海默病和其他疾病，抑制β-分泌酶酶活性和/或抑制Aβ肽在哺乳动物体内的沉积的方法，其中变量R1-R8和X在此定义。
• Organic compounds
  申请人：Baeschlin Kaspar Daniel

  公开号：US20070135498A1

  公开（公告）日：2007-06-14

  Disclosed are δ-amino-γ-hydroxy-ω-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.

  本发明涉及一种具有肾素抑制作用的δ-氨基-γ-羟基-ω-芳基-脂肪酸酰胺化合物(I)及其盐。还公开了包含这些化合物的制药组合物以及用于治疗高血压、动脉粥样硬化、不稳定性冠状动脉综合征、充血性心力衰竭、心脏肥大、心脏纤维化、心肌梗死后的心肌病、舒张功能障碍、慢性肾脏病、肝纤维化、糖尿病引起的并发症（如肾病、血管病和神经病）、冠状血管疾病、血管成形术后再狭窄、眼内压增高、青光眼、异常血管生长、高醛固酮症、认知障碍、老年痴呆症、焦虑状态和认知障碍的治疗方法。