N-glycoloyl-m-anisidine | 77775-78-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-glycoloyl-m-anisidine
• 英文别名: 2-hydroxy-N-(3-methoxyphenyl)acetamide
• CAS: 77775-78-1
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: KBRVWVFFEVSIGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氯-N-(3-甲氧基苯基)-乙酰胺 以37%的产率得到
  参考文献：
  名称：

  HAMADA TATSUO; OKUNO YOHMEI; OHMORI MASAYUKI; NISHI TAKAO; YONEMITSU OSAM+, CHEM. AND PHARM. BULL. 1981, 29, NO 1, 128-136

  摘要：

  DOI：

文献信息

• Photochemical synthesis of 1,2,3,4-tetrahydroisoquinolin-3-ones and oxindoles from N-chloroacetyl derivatives of benzylamines and anilines. Role of intramolecular exciplex formation and cis conformation of amide bonds.
  作者：TATSUO HAMADA、YOHMEI OKUNO、MASAYUKI OHMORI、TAKAO NISHI、OSAMU YONEMITSU

  DOI：10.1248/cpb.29.128

  日期：——

  Although N-chloroacetyl derivatives of benzylamines (2, 8) and anilines (21, 25, 29) disappeared quite rapidly when irradiated with a high pressure mercury lamp, no photocyclization to six- and five-membered lactams occurred. Measurements of fluorescence quenching and disappearance quantum yields of N-chloroacetyl-(3, 4-dimethoxylphenyl)-alkylamines having various lengths of alkyl chain revealed that the shorter the alkyl chain is, the more efficient the exciplex formation is. Therefore, the failure of photocyclization seemed to be due to trans conformation of amide bonds in the benzylamine and aniline derivatives. Introduction of an alkyl group on the amide nitrogen changed the stable conformation of amides from trans to cis, and hence N-alkyl-N-chloroacetylbenzylamines (11, 13, 15, 17, 19) readily gave the corresponding 1, 2, 3, 4-tetrahydroisoquinolin-3-ones (12, 14, 16, 18, 20) on irradiation. Oxindoles (36, 38, 40, 41, 43, 46) were similarly synthesized by photocyclization of N-alkyl-N-chloroacetylanilines (35, 37, 39, 42, 45).

  虽然苄胺（2、8）和苯胺（21、25、29）的 N-氯乙酰基衍生物在高压汞灯照射下会迅速消失，但并没有发生六元和五元内酰胺的光环化反应。对不同烷基链长度的 N-氯乙酰基-(3, 4-二甲氧基苯基)-烷基胺的荧光淬灭和消失量子产率的测量表明，烷基链越短，形成复合物的效率越高。因此，光环化失败似乎是由于苄胺和苯胺衍生物中酰胺键的反式构象造成的。因此，N-烷基-N-氯乙酰基苄胺（11、13、15、17、19）在辐照下很容易生成相应的 1、2、3、4-四氢异喹啉-3-酮（12、14、16、18、20）。通过 N-烷基-N-氯乙酰苯胺（35、37、39、42、45）的光环化反应，也同样合成了氧化吲哚（36、38、40、41、43、46）。
• Novel compounds for use in weight loss and appetite suppression in humans
  申请人：——

  公开号：US20040192669A1

  公开（公告）日：2004-09-30

  Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C 1 -C 4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to act as weight loss agents, appetite suppressants, mood enhancers and adjunctive therapy for arthritis, sleep apnea, fibromyalgia, diabetes and hyperglycemia. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

  从单子叶植物中获得的含有苯酚分子的苯酚化合物，其中与氧含有基团，氮或另一个氧含有基团以及C1-C4烷氧基共价连接，或通过化学合成，已被发现可作为减肥剂、食欲抑制剂、情绪增强剂和关节炎、睡眠呼吸暂停、纤维肌痛、糖尿病和高血糖的辅助治疗剂。本发明的其他化学化合物可能包括苯并噁唑啉-环状羟基酰胺、内酰胺和相应的葡萄糖苷，这些化合物可能作为苯酚化合物的前体。本发明的苯酚化合物和苯酚化合物的前体，在适合人类治疗使用的浓度下，可以从单子叶植物中获得，例如在它们的早期生长状态下收获以获得最佳产量的玉米。
• Method and composition for increasing reproduction in mammalian and avian species
  申请人：THE UNIVERSITY OF UTAH

  公开号：EP0070016A1

  公开（公告）日：1983-01-19

  Reproductive performance in mammalian and avian species is stimulated by administering an effective amount of one or more compounds of any of Formulas I, II or III, typically at the rate of 0.01 to 2 mg/kg/day: (I) a compound of the formula: wherein R represents C1-C4 alkoxy, with the proviso that R is in the 4 or 5 ring position, n represents the integers 0, 1 or 2, and A represents -OH, -NH2 or where R' represents C1-C4 alkyl, or physiologically acceptable salts thereof; (11) a compound of the formula: wherein R represents C1-C4 alkoxy, with the proviso that R is in the 5 or 6 ring position, and n represents one of the integers 0, 1 or 2; and (III) a compound of the formula: wherein R represents C1-C4 alkoxy, with the proviso that R is in the 6 or 7 ring position, and n represents one of the integers 0, 1 or 2; or physiologically acceptable salts thereof. The active compounds are incorporated in novel feed concentrates and feed compositions or parenteral dosage forms or implants utilized according to the recited method.

  通过施用有效量的一种或多种配方 I、II 或 III 中的任何一种化合物，通常以 0.01 至 2 毫克/千克/天的剂量，可刺激哺乳动物和鸟类的繁殖性能： (I) 式中化合物： 其中 R 代表 C1-C4 烷氧基，但 R 位于 4 或 5 环位置、 n 代表整数 0、1 或 2，以及 A 代表-OH、-NH2 或 其中 R' 代表 C1-C4 烷基、 或其生理上可接受的盐类； (11) 式中化合物： 其中 R 代表 C1-C4 烷氧基，但 R 位于 5 或 6 环位置，且 n 代表 0、1 或 2 整数之一；以及 (III) 式中化合物： 其中 R 代表 C1-C4 烷氧基，但 R 位于 6 或 7 环位置，且 n 代表 0、1 或 2 整数之一； 或其生理上可接受的盐类。 根据所述方法，将活性化合物加入新型饲料浓缩物和饲料组合物或非肠外剂型或植入物中。
• 4(1H)-quinolone derivatives
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP0343574A1

  公开（公告）日：1989-11-29

  Quinolone derivatives having a quinolone structure: where Yo is 0 or S are disclosed, which are useful as a cardiac. Typical examples of the quinolone derivatives include: 6,7-dimethoxy-4(IH) quinolone (compound 6) and 5-hydroxy-6-methoxy-4(IH) quinolone (compound I) as typical compounds of the formulae[I]and[I], respectively, shown in the specification.

  公开了具有喹诺酮结构的喹诺酮衍生物： 其中 Yo 为 0 或 S 的喹诺酮衍生物，可用作强心剂。典型的喹诺酮衍生物包括6,7-二甲氧基-4(IH)喹啉酮（化合物 6）和 5-羟基-6-甲氧基-4(IH)喹啉酮（化合物 I）分别为说明书中所示的式[I]和[I]的典型化合物。
• Methods for augmenting immune defenses contemplating the administration of phenolic and indoleamine-like compounds for use in animals ans humans
  申请人：——

  公开号：US20040209877A1

  公开（公告）日：2004-10-21

  Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C 1 -C 4 alkoxy group, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to preserve and/or augment innate immune defenses in humans and animals. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human and animal therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.

  酚类化合物，其酚类分子上共价连接着一个含氧基团、一个氮或另一个含氧基团，以及一个 C 1 -C 4 烷氧基基团的酚类化合物，可从单子叶植物或通过化学合成获得，已被发现可保护和/或增强人类和动物的先天性免疫防御功能。本发明的其他化合物可包括苯并恶嗪环羟肟酸、内酰胺和相应的葡萄糖苷，它们可作为酚类化合物的前体。本发明的酚类化合物和酚类化合物前体，在适合人类和动物治疗使用的浓度下，可从单子叶植物（如玉米）中获得，这些植物处于早期生长状态，及时收获可获得最佳产量。