7-chloro-3-(methoxymethyl)-2-methyl-N-(2-methyl-5-(3-(trifluoromethyl)phenyl-carbamoyl)phenyl)-3H-imidazo[4,5-b]pyridine-6-carboxamide | 1086423-40-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 7-chloro-3-(methoxymethyl)-2-methyl-N-(2-methyl-5-(3-(trifluoromethyl)phenyl-carbamoyl)phenyl)-3H-imidazo[4,5-b]pyridine-6-carboxamide
• 英文别名: 7-chloro-3-(methoxymethyl)-2-methyl-N-[2-methyl-5-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]imidazo[4,5-b]pyridine-6-carboxamide
• CAS: 1086423-40-6
• 化学式: C₂₅H₂₁ClF₃N₅O₃
• 分子量: 531.922
• InChiKey: KMZRALAVAHPKOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  37
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  98.1
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Effervescent and effervescent-dispersion compositions for medicaments and methods of use thereof
  申请人：Gonzales Rene Gilbert

  公开号：US20050074489A1

  公开（公告）日：2005-04-07

  Pharmaceutical compositions comprising one or more medicaments in a pharmaceutically acceptable effervescent formulation. The effervescent formulation includes a first gas-dispersing component and a second gas-generating effervescent component, wherein at least one first gas is released from the first gas-dispersing component and at least one second gas is generated and evolved from the second gas-generating effervescent component, upon contact with a minimal amount of water. The formulation is placed in an aqueous vehicle wherein the formulation effervesces gases causes penetration, dispersion and distribution of the medicaments in the vehicle. The vehicle, which may be any ordinary food or beverage chosen by the patient, is then ingested by the patient for delivery of a dosage of the medicaments.

  由一种或多种药物组成的药用组合物，包含在药学上可接受的泡腾制剂中。泡腾制剂包括第一气体分散成分和第二气体生成泡腾成分，其中至少一种第一气体从第一气体分散成分中释放出来，至少一种第二气体从第二气体生成泡腾成分中产生并挥发出来。将制剂置于水性载体中，制剂产生的泡腾气体可使药物在载体中渗透、分散和分布。患者可以选择任何普通食品或饮料作为载体，然后将载体摄入体内，以提供一定剂量的药物。
• Oral medicament delivery system
  申请人：Gonzales R. Gilbert

  公开号：US20050136112A1

  公开（公告）日：2005-06-23

  Oral medicament delivery system comprising a pharmaceutical composition comprising a flexible matrix, said matrix formed of a plurality of fibers comprising a collagen-based carrier and a medicament, the composition orally dissolvable to deliver a unit dose of the medicament to a patient. The flexible composition can be dose titrated and co-administered with a second pharmaceutical formulation.

  口服给药系统包括一种药物组合物，该组合物由一种柔性基质组成，所述基质由多种纤维构成，其中包括一种基于胶原蛋白的载体和一种药物，该组合物可口服溶解，以向患者提供单位剂量的药物。该柔性组合物可与第二种药物制剂进行剂量滴定和联合给药。
• EP0660705A4
  申请人：——

  公开号：EP0660705A4

  公开（公告）日：1994-10-20
• ADVANCED DRUG DELIVERY SYSTEM AND METHOD OF TREATING PSYCHIATRIC, NEUROLOGICAL AND OTHER DISORDERS WITH CARBAMAZEPINE
  申请人：Shire Laboratories Inc.

  公开号：EP0660705B1

  公开（公告）日：1999-10-06
• NON-DESENSITIZING AMPA-RECEPTORS
  申请人：Max-Planck-Gesellschaft zur Förderungder Wissenschaften e.V.

  公开号：EP1121436A2

  公开（公告）日：2001-08-08