3,10,12-Trihydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide | 101475-71-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: 3,10,12-Trihydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide
• CAS: 101475-71-2
• 化学式: C₁₉H₁₇NO₆
• 分子量: 355.347
• InChiKey: GSQFIZQPEKLFBK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.47
• 重原子数：
  26.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  137.92
• 氢给体数：
  4.0
• 氢受体数：
  6.0

文献信息

• [EN] PROCESS FOR MAKING SARECYCLINE HYDROCHLORIDE<br/>[FR] PROCÉDÉ DE PRÉPARATION DE CHLORHYDRATE DE SARÉCYCLINE
  申请人：PARATEK PHARM INNC

  公开号：WO2019192614A1

  公开（公告）日：2019-10-10

  The described invention relates to sarecycline, related compounds, intermediates and salts thereof and processes for preparing the same.

  所描述的发明涉及到沙雷环素、相关化合物、中间体及其盐以及制备它们的方法。
• SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF
  申请人：Myers Andrew G.

  公开号：US20110009371A1

  公开（公告）日：2011-01-13

  The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The modular synthesis of tetracyclines and tetracycline analogs described provides an efficient and enantioselective route to a variety of tetracycline analogs and polycyclines previously inaccessible via earlier tetracycline syntheses and semi-synthetic methods. These analogs may be used as anti-microbial agents or anti-proliferative agents in the treatment of diseases of humans or other animals.
• 4-DEDIMETHYLAMINO TETRACYCLINE COMPOUNDS
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20150105355A1

  公开（公告）日：2015-04-16

  The present invention pertains, at least in part, to novel substituted 4-dedimethylamino tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.
• TETRACYCLINE COMPOUNDS HAVING TARGET THERAPEUTIC ACTIVITIES
  申请人：Paratek Pharmaceuticals, Inc.

  公开号：US20150141381A1

  公开（公告）日：2015-05-21

  Methods and compounds for treating diseases with tetracycline compounds having a target therapeutic activity are described.