1-{2-[3-(4-diethylamino-phenyl)-1-(2-dimethylamino-ethyl)-thioureido]-ethyl}-3-(4-trifluoromethyl-phenyl)-urea | 1044679-51-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-{2-[3-(4-diethylamino-phenyl)-1-(2-dimethylamino-ethyl)-thioureido]-ethyl}-3-(4-trifluoromethyl-phenyl)-urea
• 英文别名: 1-[2-[[4-(Diethylamino)phenyl]carbamothioyl-[2-(dimethylamino)ethyl]amino]ethyl]-3-[4-(trifluoromethyl)phenyl]urea
• CAS: 1044679-51-7
• 化学式: C₂₅H₃₅F₃N₆OS
• 分子量: 524.654
• InChiKey: OXPJBMSEKCDUKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  36
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  95
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• [EN] DIUREA DERIVATIVES<br/>[FR] DERIVES DE DIUREE
  申请人：ACTIVE BIOTECH AB

  公开号：WO2005074919A1

  公开（公告）日：2005-08-18

  The present invention relates to novel diurea derivatives that block intracellular signal transduction and thereby inhibit the production of pro-inflammatory cytokines, especially interleukin-2 (IL-2) and/or induce apoptosis in activated T-cells. It further discloses such a compound for use as a medicament, the use of said compound for the manufacturing of a medicament for the treatment of immune disorders which benefit from inhibition of production of IL-2 and other pro-inflammatory cytokines and/or induction of apoptosis in activated T-cells, a pharmaceutical composition comprising said compound and a method of treatment comprising administration of a pharmaceutically effective amount of said compound. A compound of the general formula I.

  该发明涉及一种新型利尿脲衍生物，可阻断细胞内信号转导，从而抑制促炎细胞因子的产生，特别是白细胞介素-2（IL-2），并/或诱导活化T细胞凋亡。进一步披露了这种化合物作为药物的用途，所述化合物用于制造治疗受益于抑制IL-2和其他促炎细胞因子产生和/或诱导活化T细胞凋亡的免疫紊乱的药物，包括所述化合物的药物组合物和包括所述化合物的药物学有效量的给药的治疗方法。通式I的化合物。
• Diurea derivatives
  申请人：Abramo Aina Lisbeth

  公开号：US20090118330A1

  公开（公告）日：2009-05-07

  The present invention relates to novel diurea derivatives that block intracellular signal transduction and thereby inhibit the production of pro-inflammatory cytokines, especially interleukin-2 (IL-2) and/or induce apoptosis in activated T-cells. It further discloses such a compound for use as a medicament, the use of said compound for the manufacturing of a medicament for the treatment of immune disorders which benefit from inhibition of production of IL-2 and other pro-inflammatory cytokines and/or induction of apoptosis in activated T-cells, a pharmaceutical composition comprising said compound and a method of treatment comprising administration of a pharmaceutically effective amount of said compound.

  本发明涉及新型二脲衍生物，其阻断细胞内信号转导，从而抑制炎症介质，尤其是干扰素-2（IL-2）的产生，并/或诱导活化T细胞的凋亡。本发明进一步揭示了这种化合物作为药物的用途，使用该化合物制造药物用于治疗免疫紊乱，该免疫紊乱受益于抑制IL-2和其他炎症介质的产生和/或诱导活化T细胞的凋亡，以及包含该化合物的制药组合物和治疗方法，其中包括给予该化合物的药物有效剂量。
• DIUREA DERIVATIVES
  申请人：Active Biotech AB

  公开号：EP1711175A1

  公开（公告）日：2006-10-18