2-(4-hydroxy-2-methyl-phenoxy)-propionic acid ethyl ester | 932041-81-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(4-hydroxy-2-methyl-phenoxy)-propionic acid ethyl ester
• 英文别名: Ethyl 2-(4-hydroxy-2-methylphenoxy)propanoate
• CAS: 932041-81-1
• 化学式: C₁₂H₁₆O₄
• 分子量: 224.257
• InChiKey: CKRLYFWVLSGEQB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SUBSTITUTED TRIAZOLES AS MODULATORS OF PPAR AND METHODS OF THEIR PREPARATION
  申请人：Zhu Yan

  公开号：US20080108630A1

  公开（公告）日：2008-05-08

  The present invention is directed to certain novel triazole compounds represented by Formula I and pharmaceutically acceptable salts, solvates, hydrates, and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity, and eating disorders.

  本发明涉及一些新型三唑化合物，由公式I表示，并且包括其药学上可接受的盐、溶剂化合物、水合物和前药。本发明还涉及制备和使用这些化合物的方法以及包含这些化合物的制药组合物，用于治疗或控制由PPAR介导的许多疾病，例如葡萄糖代谢、脂质代谢和胰岛素分泌，特别是2型糖尿病、高胰岛素血症、高脂血症、高尿酸血症、高胆固醇血症、动脉粥样硬化、一种或多种心血管疾病的风险因素、X综合症、高三酰甘油血症、高血糖症、肥胖症和进食障碍。
• NOVEL COMPOUNDS AND THEIR USE AS ANTIDIABETIC AND HYPOLIPIDEMIC AGENTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
  申请人：Dr. Reddy's Laboratories Ltd.

  公开号：EP1680397A2

  公开（公告）日：2006-07-19
• CONDENSED PYRAZOLE DERIVATIVES AS PPAR AGONISTS II
  申请人：Inpharmatica Limited

  公开号：EP1937647A1

  公开（公告）日：2008-07-02
• US7323480B2
  申请人：——

  公开号：US7323480B2

  公开（公告）日：2008-01-29
• [EN] NOVEL COMPOUNDS AND THEIR USE IN MEDICINE, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM<br/>[FR] NOUVEAUX COMPOSES ET LEUR UTILISATION EN MEDECINE, LEUR PROCEDE DE PREPARATION ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：REDDYS LAB LTD DR

  公开号：WO2005040102A2

  公开（公告）日：2005-05-06

  The present invention relates to novel compounds of formula (I) and their pharmaceutically acceptable salts, wherein ring “Ar1” represents a monocyclic or polycyclic aromatic or partially saturated aromatic polycyclic, which may optionally contain up to 3 heteroatoms selected from N, S or O. The said monocyclic or polycyclic ring may be unsubstituted or have up to 4 substituents which may be identical or different; m and n independently represents an integer from 0 to 6; A represents O, S or bond; Y is selected from (CH2)p’ (CH2)pB(CH2)q’ (CH2)rB(CH2)pD(CH2)q’ where p, q and r each independently represents an integer from 0 to 6; B and D independently represents S, O, NR4 or a bond, with a proviso that when B and D represents hereto atom p is not zero; R4 represents hydrogen, alkyl, alkenyl, -S(O)2-R8 or -C(O)R8 where R8 is alkyl, alkoxy; R5 and R6 independently represents hydrogen, alkyl, cycloalkyl or alkoxy; R5 and R6 together may form 3-8 membered cyclic ring which may optionally contains one or two hereto atoms selected from O, S or N; R7 represents hydrogen, optionally substituted groups selected form alkyl, cycloalkyl, alkenyl or alkynyl. The present invention also relates to a process for preparation of compounds of formula (I), to pharmaceutical compositions containing compounds of formula (I) and their use in particular as antidiabetic, hypolipidemic, antiobesity and hypocholesterolemic agents.